Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 2/20 | 0.51 |
| ▸ | ATP4B | P51164 | 2/20 | 0.51 |
| ▸ | CDC25A | P30304 | 3/20 | 0.44 |
| ▸ | CDC25B | P30305 | 3/20 | 0.44 |
| ▸ | CDC25C | P30307 | 3/20 | 0.44 |
| ▸ | DUSP3 | P51452 | 3/20 | 0.44 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.43 |
| ▸ | EIF4E | P06730 | 2/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14224938 | 0.90 | CDC25A (0.53) | ATP4AATP4BCDC25ACDC25BCDC25C | |
| SCHEMBL14224937 | 0.90 | ATP4A (0.53) | ATP4AATP4BSREBF2EIF4EMAPT | |
| SCHEMBL14224966 | 0.85 | ATP4A (0.56) | ATP4AATP4BCDC25ACDC25BCDC25C | |
| SCHEMBL14224914 | 0.84 | HPGD (0.50) | ATP4AATP4BSCN9AMAPTGAA | |
| SCHEMBL14224939 | 0.83 | ATP4A (0.61) | ATP4AATP4BCDC25ACDC25BCDC25C | |
| SCHEMBL16404137 | 0.83 | ATP4A (0.56) | ATP4AATP4BEIF4EMAPTGAA | |
| SCHEMBL14224947 | 0.83 | MAPK1 (0.59) | ATP4AATP4BEIF4EMAPTNPC1 | |
| SCHEMBL16404108 | 0.83 | ATP4A (0.56) | ATP4AATP4BEIF4EMAPTNPC1 | |
| SCHEMBL14315466 | 0.83 | ATP4A (0.58) | ATP4AATP4BCDC25ACDC25BCDC25C | |
| SCHEMBL16404008 | 0.82 | ATP4A (0.60) | ATP4AATP4BCDC25ACDC25BCDC25C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8937065-B2 | Compositions and methods for modulating a kinase | CLEVEXEL PHARMA (FR) | 2015-01-20 | — | — | US | disclosed |