SCHEMBL16404256

SCHEMBL16404256

CCc1c(C(=O)NCC23CC4CC(CC(C4)C2)C3)nc(C)n1-c1ccccc1

nearest known ligand 0.74

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 11/20 0.74
CNR1 P21554 8/20 0.61
P2RX7 Q99572 7/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16404193 0.85 CNR2 (1.00) CNR2CNR1
SCHEMBL16404249 0.79 CNR2 (0.78) CNR2CNR1
SCHEMBL16404195 0.77 CNR2 (0.84) CNR2CNR1
SCHEMBL16404259 0.76 CNR2 (1.00) CNR2CNR1
SCHEMBL16404221 0.74 CNR2 (0.79) CNR2CNR1
SCHEMBL15419365 0.73 P2RX7 (0.49) CNR2CNR1P2RX7
SCHEMBL16404247 0.71 CNR2 (0.57) CNR2CNR1
SCHEMBL3687439 0.71 CNR2 (1.00) CNR2CNR1
SCHEMBL16404225 0.70 CNR2 (0.56) CNR2CNR1
SCHEMBL14888794 0.70 P2RX7 (0.46) P2RX7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8937184-B2 1H-imidazole derivatives as cannabinoid CB2 receptor modulators ABBVIE B.V. (NL) 2015-01-20 US disclosed
US-8937184-B2 1H-imidazole derivatives as cannabinoid CB2 receptor modulators ABBVIE B.V. (NL) 2015-01-20 US disclosed