Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGA2 | P17301 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | COMT | P21964 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.36 |
| ▸ | PORCN | Q9H237 | 3/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.35 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12766572 | 0.84 | KMT2A (0.40) | ITGB1ITGA2CTSAALDH1A1KDM4E | |
| SCHEMBL1641514 | 0.80 | ALDH1A1 (0.46) | ALDH1A1KDM4ENPC1LMNARAB9A | |
| SCHEMBL1529509 | 0.76 | KDM4E (0.47) | ITGB1ITGA2ALDH1A1KDM4ENPC1 | |
| SCHEMBL24956340 | 0.74 | COMT (0.39) | ITGB1ITGA2CTSAALDH1A1KDM4E | |
| SCHEMBL1539528 | 0.74 | HCAR2 (0.45) | CTSAALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL3330957 | 0.71 | PORCN (0.42) | CTSAALDH1A1KDM4ECOMTPOLB | |
| SCHEMBL12766571 | 0.71 | AHR (0.40) | ALDH1A1KDM4ENPC1LMNARAB9A | |
| SCHEMBL937627 | 0.71 | DAO (0.42) | ITGB1ITGA2CTSAALDH1A1MAPT | |
| SCHEMBL1682702 | 0.71 | CTSA (0.38) | CTSAALDH1A1KDM4ENPC1LMNA | |
| SCHEMBL1539536 | 0.69 | CYP11B1 (0.42) | ALDH1A1KDM4ENPC1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098221-A1 | INHIBITORS OF Akt ACTIVITY | GLAXOSMITHKLINE LLC | 2011-04-28 | — | — | US | disclosed |
| US-20110098221-A1 | INHIBITORS OF Akt ACTIVITY | GLAXOSMITHKLINE LLC | 2011-04-28 | — | — | US | disclosed |
| US-20110098221-A1 | INHIBITORS OF Akt ACTIVITY | GLAXOSMITHKLINE LLC | 2011-04-28 | — | — | US | disclosed |
| EP-2303277-A1 | INHIBITORS OF AKT ACTIVITY | GlaxoSmithKline LLC (US) | 2011-04-06 | — | — | EP | disclosed |
| WO-2009158373-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-30 | — | — | WO | disclosed |
| WO-2009158373-A1 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098221-A1 | INHIBITORS OF Akt ACTIVITY | AKT2, AKT1, PIK3CA | ITGB1 3624/4885ITGA2 4243/4885CTSA 2431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.