SCHEMBL16405352

SCHEMBL16405352

COC(=O)Oc1ccc(C(C)(C)c2ccc(C(C)(C)C)cc2)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.51
TDP1 Q9NUW8 2/20 0.51
L3MBTL1 Q9Y468 2/20 0.51
ALDH1A1 P00352 3/20 0.50
HSD17B10 Q99714 2/20 0.50
RECQL P46063 2/20 0.50
LMNA P02545 1/20 0.50
ALOX15 P16050 1/20 0.50
APEX1 P27695 1/20 0.50
MAPK1 P28482 1/20 0.50
NPSR1 Q6W5P4 2/20 0.49
RAB9A P51151 4/20 0.47
SMN1; SMN2 Q16637 2/20 0.47
NPC1 O15118 2/20 0.47
HTT P42858 1/20 0.47
MEN1 O00255 4/20 0.46
KMT2A Q03164 4/20 0.46
EPHX2 P34913 1/20 0.44
NR1H4 Q96RI1 1/20 0.44
THRB P10828 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1790162 0.94 MAPT (0.56) MAPTTDP1L3MBTL1ALDH1A1HSD17B10
SCHEMBL6934422 0.94 ELANE (0.46) MAPTTDP1L3MBTL1ALDH1A1HSD17B10
SCHEMBL477017 0.91 MAPT (0.56) MAPTTDP1L3MBTL1ALDH1A1HSD17B10
SCHEMBL3424216 0.89 MAPT (0.51) MAPTTDP1L3MBTL1ALDH1A1HSD17B10
SCHEMBL13799434 0.88 ESR1 (0.55) MAPTTDP1L3MBTL1ALDH1A1HSD17B10
SCHEMBL410353 0.88 LMNA (0.48) MAPTTDP1ALDH1A1LMNANPSR1
SCHEMBL16405354 0.88 ELANE (0.45) MAPTTDP1L3MBTL1ALDH1A1LMNA
SCHEMBL12313789 0.88 KDM4E (0.51) MAPTTDP1L3MBTL1ALDH1A1LMNA
SCHEMBL3424446 0.86 KDM4E (0.50) MAPTTDP1L3MBTL1ALDH1A1LMNA
SCHEMBL19846658 0.86 TDP1 (0.49) MAPTTDP1L3MBTL1ALDH1A1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4177293-A1 METHODS FOR PRODUCING POLYCARBONATE COPOLYMER AND POLYSILOXANE COMPOUND, POLYCARBONATE COPOLYMER, POLYSILOXANE COMPOUND, COMPOSITION, AND MOLDED BODY MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2023-05-10 EP disclosed
EP-4177291-A1 METHODS FOR PRODUCING POLYCARBONATE COPOLYMER AND POLYSILOXANE COMPOUND, POLYCARBONATE COPOLYMER, POLYSILOXANE COMPOUND, COMPOSITION, AND MOLDED BODY MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2023-05-10 EP disclosed
EP-4177292-A1 METHODS FOR PRODUCING POLYCARBONATE COPOLYMER AND POLYSILOXANE COMPOUND, POLYCARBONATE COPOLYMER, POLYSILOXANE COMPOUND, COMPOSITION, AND MOLDED BODY MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2023-05-10 EP disclosed
US-9201318-B2 Polymer for charge generation layer and charge transport layer formulation XEROX CORPORATION (US) 2015-12-01 US disclosed
US-20150024310-A1 POLYMER FOR CHARGE GENERATION LAYER AND CHARGE TRANSPORT LAYER FORMULATION XEROX CORPORATION 2015-01-22 US disclosed