Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 5/20 | 0.66 |
| ▸ | KMO | O15229 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | IL1RN | P18510 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1000570 | 1.00 | AKR1C3 (0.66) | AKR1C3KMOMAPTIL1RNALDH1A1 | |
| SCHEMBL2566255 | 0.98 | AKR1C3 (0.68) | AKR1C3KMOMAPTIL1RNALDH1A1 | |
| SCHEMBL30921570 | 0.98 | AKR1C3 (0.68) | AKR1C3KMOMAPTIL1RNALDH1A1 | |
| SCHEMBL31192547 | 0.92 | AKR1C3 (0.71) | AKR1C3KMOMAPTIL1RNALDH1A1 | |
| SCHEMBL21225183 | 0.92 | AKR1C3 (0.71) | AKR1C3KMOMAPTIL1RNALDH1A1 | |
| SCHEMBL26144972 | 0.84 | AKR1C3 (0.55) | AKR1C3KMOMAPTIL1RNALDH1A1 | |
| SCHEMBL29503132 | 0.84 | GAA (0.55) | AKR1C3ALDH1A1KMT2ALMNA | |
| SCHEMBL18383378 | 0.82 | AKR1C3 (0.48) | AKR1C3ALDH1A1EPHX2KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL5130887 | 0.82 | AKR1C3 (0.56) | AKR1C3KMOMAPTIL1RNALDH1A1 | |
| SCHEMBL16903002 | 0.82 | SMN1; SMN2 (0.62) | MAPTALDH1A1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150025235-A1 | Benzamide Compounds and Related Methods of Use | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-01-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150025235-A1 | Benzamide Compounds and Related Methods of Use | SIRT2, SIRT1, SIRT3 | AKR1C3 3742/4885KMO 989/4885MAPT 248/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.