Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACAT2 | Q9BWD1 | 4/20 | 0.57 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.30 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16410770 | 0.90 | ACAT2 (0.44) | ACAT2MAPTLMNATDP1KDM4E | |
| SCHEMBL16410830 | 0.84 | ACAT2 (0.57) | ACAT2HTR2CHTR2BSLC6A2SLC6A4 | |
| SCHEMBL16410532 | 0.84 | ACAT2 (0.44) | ACAT2MAPTLMNASLC6A2SLC6A4 | |
| SCHEMBL16410712 | 0.79 | ACAT2 (0.38) | ACAT2MAPTKDM4E | |
| SCHEMBL16410667 | 0.78 | ACAT2 (0.38) | ACAT2HTR2CMAPTKDM4E | |
| SCHEMBL16410828 | 0.77 | ACAT2 (0.36) | ACAT2MAPTKDM4E | |
| SCHEMBL17757304 | 0.77 | ACAT2 (0.50) | ACAT2HTR2CHTR2BLMNA | |
| SCHEMBL16410784 | 0.76 | ACAT2 (0.43) | ACAT2SLC6A4 | |
| SCHEMBL16410741 | 0.76 | PDE7A (0.33) | ACAT2 | |
| SCHEMBL16410766 | 0.76 | ACAT2 (0.47) | ACAT2HTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015007730-A1 | SPIROQUINOXALINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2015-01-22 | — | — | WO | disclosed |