Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACAT2 | Q9BWD1 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16410620 | 0.89 | ACAT2 (0.36) | ACAT2KMT2AKDM4EMAPTNPC1 | |
| SCHEMBL16410830 | 0.82 | ACAT2 (0.57) | ACAT2CYP2C9CYP2C19HTR2C | |
| SCHEMBL16410532 | 0.80 | ACAT2 (0.44) | ACAT2MEN1ALDH1A1KMT2AMAPT | |
| SCHEMBL16410755 | 0.80 | ACAT2 (0.43) | ACAT2MEN1ALDH1A1TSHRKMT2A | |
| SCHEMBL16410750 | 0.79 | ACAT2 (0.39) | ACAT2CYP2C9CYP2C19KMT2A | |
| SCHEMBL16410759 | 0.78 | ACAT2 (0.57) | ACAT2KDM4EMAPTHTR2C | |
| SCHEMBL16410726 | 0.78 | ALDH1A1 (0.32) | ACAT2ALDH1A1KMT2AKDM4EMAPT | |
| SCHEMBL16410789 | 0.78 | ACAT2 (0.38) | ACAT2MEN1ALDH1A1CYP2C9CYP2C19 | |
| SCHEMBL16410784 | 0.77 | ACAT2 (0.43) | ACAT2MEN1ALDH1A1CYP2C9TSHR | |
| SCHEMBL16410712 | 0.75 | ACAT2 (0.38) | ACAT2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015007730-A1 | SPIROQUINOXALINE DERIVATIVES AS INHIBITORS OF NON-APOPTOTIC REGULATED CELL-DEATH | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2015-01-22 | — | — | WO | disclosed |