Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | NAAA | Q02083 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15659169 | 1.00 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2PKMGAAHDAC3 | |
| SCHEMBL15657795 | 1.00 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2PKMGAAHDAC3 | |
| SCHEMBL15662096 | 1.00 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2PKMGAAHDAC3 | |
| SCHEMBL15659605 | 0.86 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2PKMGAAHDAC3 | |
| SCHEMBL15660528 | 0.86 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2PKMGAAHDAC3 | |
| SCHEMBL15657310 | 0.86 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2PKMGAAHDAC3 | |
| SCHEMBL9784444 | 0.81 | SMN1; SMN2 (0.84) | ALDH1A1SMN1; SMN2PKMGAAHDAC3 | |
| SCHEMBL2719119 | 0.81 | SMN1; SMN2 (0.84) | ALDH1A1SMN1; SMN2PKMGAAHDAC3 | |
| SCHEMBL15999997 | 0.81 | SMN1; SMN2 (0.84) | ALDH1A1SMN1; SMN2PKMGAAHDAC3 | |
| SCHEMBL15660301 | 0.81 | NAAA (0.63) | ALDH1A1HDAC3NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150031892-A1 | SPHINGOLIPID METABOLITE MIMETICS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2015-01-29 | — | — | US | claimed |
| US-20150031892-A1 | SPHINGOLIPID METABOLITE MIMETICS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2015-01-29 | — | — | US | disclosed |
| US-20150031892-A1 | SPHINGOLIPID METABOLITE MIMETICS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2015-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150031892-A1 | SPHINGOLIPID METABOLITE MIMETICS | BID, BAD, S1PR1 | ALDH1A1 2945/4885SMN1; SMN2 900/4885PKM 3322/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.