Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.56 |
| ▸ | GHSR | Q92847 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.44 |
| ▸ | FASN | P49327 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL857503 | 0.76 | RIPK1 (0.64) | GHSRHPGDMAPK1RIPK1 | |
| SCHEMBL16417008 | 0.74 | HRH3 (0.53) | PARP1ALDH1A1 | |
| SCHEMBL1355458 | 0.74 | GHSR (0.71) | GHSRHPGDALDH1A1NPC1RAB9A | |
| SCHEMBL29944074 | 0.74 | GHSR (0.71) | GHSRHPGDALDH1A1NPC1RAB9A | |
| SCHEMBL857458 | 0.72 | IKBKB (0.63) | HPGDALDH1A1RIPK1BRD4 | |
| SCHEMBL23675226 | 0.72 | PLK4 (0.56) | HPGDALDH1A1RIPK1 | |
| SCHEMBL16416385 | 0.72 | PARP1 (1.00) | PARP1HPGDALDH1A1NPC1RAB9A | |
| SCHEMBL7132525 | 0.72 | HPGD (1.00) | HPGDALDH1A1MAPK1TSHR | |
| SCHEMBL27479149 | 0.72 | HPGD (1.00) | HPGDALDH1A1MAPK1TSHR | |
| SCHEMBL857035 | 0.71 | IKBKB (0.64) | RIPK1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015011008-A1 | 7-AZAINDOLE DERIVATIVES AS PARP INHIBITORS | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2015-01-29 | — | — | WO | disclosed |