Poldine

Poldine

SCHEMBL1641786

C[N+]1(C)CCCC1COC(=O)C(O)(c1ccccc1)c1ccccc1

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ CHRM2 P08172 11/20 0.55
▸ CHRM3 P20309 11/20 0.55
▸ CYP2D6 P10635 4/20 0.55
▸ KCNH2 Q12809 4/20 0.55
▸ LMNA P02545 2/20 0.55
▸ SLC6A4 P31645 2/20 0.55
▸ CYP2C19 P33261 1/20 0.55
▸ SLC22A1 O15245 1/20 0.54
▸ CHRM1 P11229 5/20 0.54
▸ HRH1 P35367 2/20 0.54
▸ RAB9A P51151 1/20 0.53
▸ CHRM4 P08173 3/20 0.49
▸ CHRM5 P08912 3/20 0.49
▸ CHRNB2 P17787 2/20 0.45
▸ CHRNB4 P30926 2/20 0.45
▸ CHRNA3 P32297 2/20 0.45
▸ CHRNA7 P36544 2/20 0.45
▸ CHRNA4 P43681 2/20 0.45
▸ ALDH1A1 P00352 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bevonium SCHEMBL1650540 0.96 CHRM2 (0.51) CHRM2CHRM3CYP2D6KCNH2LMNA
Poldine SCHEMBL250977 0.92 CHRM2 (0.48) CHRM2CHRM3CYP2D6KCNH2LMNA
Bevonium SCHEMBL28086190 0.91 CHRM2 (0.47) CHRM2CHRM3CYP2D6KCNH2LMNA
Bevonium SCHEMBL28439272 0.90 CHRM2 (0.46) CHRM2CHRM3CYP2D6KCNH2LMNA
Bevonium SCHEMBL25016 0.89 CHRM2 (0.45) CHRM2CHRM3CYP2D6KCNH2LMNA
Oxypyrronium SCHEMBL29388831 0.84 POLB (0.57) CHRM2CHRM3CYP2D6KCNH2LMNA
Oxypyrronium SCHEMBL916858 0.83 CHRM2 (0.56) CHRM2CHRM3CYP2D6KCNH2LMNA
Poldine SCHEMBL28086707 0.83 CHRM2 (0.67) CHRM2CHRM3CYP2D6KCNH2LMNA
SCHEMBL1087914 0.81 CHRM2 (0.47) CHRM2CHRM3CYP2D6KCNH2LMNA
SCHEMBL1087915 0.81 CHRM2 (0.47) CHRM2CHRM3CYP2D6KCNH2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 359 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4154879-B1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING NICOTINE WITHDRAWAL SYMPTOMS KOREA INST SCI & TECH (KR) 2025-09-10 — — EP claimed
EP-4154879-A1 PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING NICOTINE WITHDRAWAL SYMPTOMS Korea Institute of Science and Technology (KR) 2023-03-29 — — EP claimed
US-11065205-B2 Immediate/delayed drug delivery DRUG DELIVERY INTERNATIONAL LIMITED (GB) 2021-07-20 — — US claimed
US-10689370-B2 Cyclopropane carboxamide modulators of cystic fibrosis transmembrane conductance regulator AUSPEX PHARMACEUTICALS, INC. (US) 2020-06-23 — — US claimed
US-20190125679-A1 IMMEDIATE/DELAYED DRUG DELIVERY UNIVERSITY OF STRATHCLYDE (GB) 2019-05-02 — — US claimed
EP-3373943-A1 CONTROL OF CELLULAR REDOX LEVELS Mckenna, Elizabeth (US) 2018-09-19 — — EP claimed
CN-108430482-A Control of cellular redox levels 伊丽莎白·麦克纳 2018-08-21 — — CN claimed
EP-2956450-B1 HYDROXYINDALPINE DERIVATIVES AND THEIR MEDICAL USE UNIV MUENCHEN TECH (DE) 2018-07-25 — — EP claimed
EP-2542228-B1 PULSATILE DRUG RELEASE UNIV STRATHCLYDE (GB) 2017-11-29 — — EP claimed
EP-2542226-B1 DELAYED PROLONGED DRUG DELIVERY UNIV STRATHCLYDE (GB) 2017-11-22 — — EP claimed
WO-2008059190-A1 TREATMENT OF EXCESS SEBUM PRODUCTION SUMMIT (CAMBRIDGE) LIMITED (GB) 2008-05-22 — — WO claimed
WO-2007141530-A2 TREATMENT OF EXCESS SEBUM PRODUCTION SUMMIT (CAMBRIDGE) LIMITED (GB) 2007-12-13 — — WO claimed
WO-2007135574-A1 USE OF PARASYMPATHOLYTIC SUBSTANCES TO ENHANCE AND ACCELERATE STEM CELL DIFFERENTIATION, RELATED METHOD AND COMPOSITIONS UNIVERSITA' DEGLI STUDI DI TORINO (IT) 2007-11-29 — — WO claimed
WO-2007061529-A1 LYOPHILIZATION PROCESS AND PRODUCTS OBTAINED THEREBY SCIDOSE LLC. (US) 2007-05-31 — — WO claimed
US-20070116729-A1 Lyophilization process and products obtained thereby SCIDOSE LLC 2007-05-24 — — US claimed
EP-1273301-B1 Pharmaceutical preparations based on active ingredients susceptible to illicit administration ALTERGON SA (CH) 2006-09-06 — — EP claimed
EP-1202723-A2 USE OF ANTI-MUSCARINIC AGENTS FOR TREATING SKIN DISORDERS Arakis Limited (GB) 2002-05-08 — — EP claimed
WO-2001010427-A2 USE OF ANTI-MUSCARINIC AGENTS FOR TREATING SKIN DISORDERS ARAKIS LIMITED (GB) 2001-02-15 — — WO claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 — — EP claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 — — WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10689370-B2 Cyclopropane carboxamide modulators of cystic fibrosis transmembrane conductance regulator CFTR, CLCN2, TMEM120A CHRM2 1950/4885CHRM3 748/4885CYP2D6 4330/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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