Oxypyrronium

Oxypyrronium

SCHEMBL916858

C[N+]1(C)CCCC1COC(=O)C(O)(c1ccccc1)C1CCCCC1.[Br-]

nearest known ligand 0.56

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1

The experimentally established mechanism targets of Oxypyrronium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 known ✓ P08172 5/20 0.56
CHRM3 known ✓ P20309 5/20 0.56
CHRM1 known ✓ P11229 4/20 0.56
CHRM4 known ✓ P08173 2/20 0.56
CHRM5 known ✓ P08912 2/20 0.56
OPRM1 known ✓ P35372 1/20 0.53
KCNH2 Q12809 4/20 0.56
HTR2B P41595 2/20 0.56
HRH1 P35367 2/20 0.56
POLB P06746 1/20 0.56
ALDH1A1 P00352 1/20 0.56
SLC6A3 Q01959 2/20 0.54
CYP2C19 P33261 2/20 0.53
CYP3A4 P08684 2/20 0.53
CYP1A2 P05177 1/20 0.53
CYP2D6 P10635 1/20 0.53
CYP2C9 P11712 1/20 0.53
PKM P14618 1/20 0.53
NFKB1 P19838 1/20 0.53
THPO P40225 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Oxypyrronium SCHEMBL29388831 0.99 POLB (0.57) CHRM2CHRM3CHRM1KCNH2CHRM4
Poldine SCHEMBL1641786 0.83 CHRM2 (0.55) CHRM2CHRM3CHRM1KCNH2CHRM4
SCHEMBL5252511 0.83 POLB (0.51) CHRM2CHRM3CHRM1KCNH2CHRM4
SCHEMBL1086651 0.83 POLB (0.51) CHRM2CHRM3CHRM1KCNH2CHRM4
SCHEMBL1086653 0.83 POLB (0.51) CHRM2CHRM3CHRM1KCNH2CHRM4
SCHEMBL1086654 0.83 POLB (0.51) CHRM2CHRM3CHRM1KCNH2CHRM4
SCHEMBL1086380 0.83 POLB (0.50) CHRM2CHRM3CHRM1KCNH2CHRM4
SCHEMBL5245016 0.83 POLB (0.50) CHRM2CHRM3CHRM1KCNH2CHRM4
SCHEMBL1086386 0.83 POLB (0.50) CHRM2CHRM3CHRM1KCNH2CHRM4
SCHEMBL1086383 0.83 POLB (0.50) CHRM2CHRM3CHRM1KCNH2CHRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117196693-B Logistics demand prediction method for urban underground traffic 西南交通大学 2024-03-26 CN claimed
CN-117196693-A Logistics demand prediction method for urban underground traffic 西南交通大学 2023-12-08 CN claimed
EP-4088717-A1 USE AND COMPOSITION FOR TREATING DEMENTIA Chase Pharmaceuticals Corporation (US) 2022-11-16 EP disclosed
EP-4035668-A1 ANTICHOLINERGIC NEUROPROTECTIVE COMPOSITION AND METHODS Chase Pharmaceuticals Corporation (US) 2022-08-03 EP disclosed
US-20210128528-A1 USE OF 5HT2A INVERSE AGONISTS FOR TREATING PSYCHOSIS AXOVANT SCIENCES GMBH (CH) 2021-05-06 US disclosed
US-20190314354-A1 MUSCARINIC COMBINATIONS AND THEIR USE FOR COMBATING HYPOCHOLINERGIC DISORDERS OF THE CENTRAL NERVOUS SYSTEM CHASE PHARMACEUTICALS CORPORATION (US) 2019-10-17 US disclosed
US-10307409-B2 Muscarinic combinations and their use for combating hypocholinergic disorders of the central nervous system CHASE PHARMACEUTICALS CORPORATION (US) 2019-06-04 US disclosed
US-20190091214-A1 USE AND COMPOSITION FOR TREATING DEMENTIA CHASE PHARMACEUTICALS CORP (US) 2019-03-28 US disclosed
WO-2019033068-A1 USE OF 5HT2A INVERSE AGONISTS FOR TREATING PSYCHOSIS AXOVANT SCIENCES GMBH (CH) 2019-02-14 WO disclosed
US-20190046506-A1 USE OF 5HT2A INVERSE AGONISTS FOR TREATING PSYCHOSIS AXOVANT SCIENCES GMBH (CH) 2019-02-14 US disclosed
US-20190000826-A1 ANTICHOLINERGIC NEUROPROTECTIVE COMPOSITION AND METHODS CHASE PHARMACEUTICALS CORPORATION (US) 2019-01-03 US disclosed
US-6180823-B1 CONDENSING SUBSTITUTED ACETALDEHYDE WITH ENANTIOMER OF MANDELIC ACID TO PROVIDE 5-PHENYL-1,3-DIOXOLAN-4-ONE, CONDENSING WITH CYCLOHEXANONE, DEHYDRATING PRODUCT, HYDROLYZING, REDUCING TO ALPHA-CYCLOHEXYLPHENYLGLYCOLIC ACID SEPRACOR INC. 2001-01-30 US disclosed
US-6140529-A Synthesis of optically active cyclohexylphenylglycolate esters SEPRACOR INC. (US) 2000-10-31 US disclosed
US-6090971-A Resolution process for cyclohexylphenyl glycolic acid SEPRACOR INC. (US) 2000-07-18 US disclosed
WO-2000027786-A1 STEREOSELECTIVE PROCESS FOR PREPARING (CYCLO)ALKYL PHENYLGLYCOLIC ACIDS SEPRACOR INC. (US) 2000-05-18 WO disclosed
WO-2000023414-A2 SYNTHESIS OF OPTICALLY ACTIVE CYCLOHEXYLPHENYLGLYCOLIC ACID AND ITS ESTERS SEPRACOR INC. (US) 2000-04-27 WO disclosed
US-6025177-A ENANTIOSELECTIVE SYNTHESIS OF CHIRAL ALPHA-HYDROXYCARBOXYLATE BY REACTING A PROCHIRAL ALPHA-KETOCARBOXYLIC ACID WITH A SINGLE ENANTIOMER OF AN N-SUBSTITUTED VICINAL AMINOALCOHOL OF SPECIFIC CYCLOHYDROCARBONS TO FORM ALPHA-HYDROXYCARBOXYLATE SEPRACOR INC. (US) 2000-02-15 US disclosed
US-6013830-A CHEMICAL INTERMEDIATES FOR OXYBUTYNIN, OXYPHENCYCLIMINE, OXYPHENONIUM BROMIDE, OXYPYRRONIUM BROMIDE, AND OXYSONIUM IODIDE, FOR WHICH CYCLOHEXYLPHENYLGLYCOLIC ACID (CHPGA) IS OF SPECIAL INTEREST; STEREOSELECTIVITY SEPRACOR INC. (US) 2000-01-11 US disclosed
US-5973182-A Carbonate Intermediates useful in the preparation of optically active cyclohexylphenylglycolate esters SEPRACOR INC. (US) 1999-10-26 US disclosed
WO-1999050205-A2 ASYMMETRIC GRIGNARD SYNTHESIS WITH CYCLIC 1,2 AMINOALCOHOLS SEPRACOR INC. (US) 1999-10-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190314354-A1 MUSCARINIC COMBINATIONS AND THEIR USE FOR COMBATING HYPOCHOLINERGIC DISORDERS OF THE CENTRAL NERVOUS SYSTEM CHRM3, CHRM2, CHRM4 CHRM2 2/4885CHRM3 1/4885CHRM1 5/4885
US-10307409-B2 Muscarinic combinations and their use for combating hypocholinergic disorders of the central nervous system CHRM3, CHRM2, CHRM4 CHRM2 2/4885CHRM3 1/4885CHRM1 5/4885
US-20190000826-A1 ANTICHOLINERGIC NEUROPROTECTIVE COMPOSITION AND METHODS ACHE, CHRNA5, SNCA CHRM2 46/4885CHRM3 32/4885CHRM1 60/4885
US-20190091214-A1 USE AND COMPOSITION FOR TREATING DEMENTIA ACHE, BCHE, CHAT CHRM2 11/4885CHRM3 18/4885CHRM1 25/4885
US-20210128528-A1 USE OF 5HT2A INVERSE AGONISTS FOR TREATING PSYCHOSIS HTR2A, HTR1A, HTR3B CHRM2 251/4885CHRM3 299/4885CHRM1 369/4885
US-20190046506-A1 USE OF 5HT2A INVERSE AGONISTS FOR TREATING PSYCHOSIS HTR2A, HTR1A, HTR3B CHRM2 251/4885CHRM3 299/4885CHRM1 369/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.