Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bevonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 11/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 11/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 2/20 | 0.46 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bevonium SCHEMBL1650540 | 0.94 | CHRM2 (0.51) | CHRM2CHRM3CHRM1CYP2D6CHRM4 | |
| Poldine SCHEMBL1641786 | 0.91 | CHRM2 (0.55) | CHRM2CHRM3CHRM1CYP2D6CHRM4 | |
| Bevonium SCHEMBL28439272 | 0.88 | CHRM2 (0.46) | CHRM2CHRM3CHRM1CYP2D6CHRM4 | |
| Bevonium SCHEMBL25016 | 0.87 | CHRM2 (0.45) | CHRM2CHRM3CHRM1CYP2D6CHRM4 | |
| Poldine SCHEMBL250977 | 0.83 | CHRM2 (0.48) | CHRM2CHRM3CHRM1CYP2D6CHRM4 | |
| Oxypyrronium SCHEMBL29388831 | 0.79 | POLB (0.57) | CHRM2CHRM3CHRM1CYP2D6CHRM4 | |
| Oxypyrronium SCHEMBL916858 | 0.78 | CHRM2 (0.56) | CHRM2CHRM3CHRM1CYP2D6CHRM4 | |
| Poldine SCHEMBL28086707 | 0.77 | CHRM2 (0.67) | CHRM2CHRM3CHRM1CYP2D6CHRM4 | |
| SCHEMBL14166722 | 0.76 | CHRM3 (0.63) | CHRM2CHRM3CHRM1CYP2D6CHRM4 | |
| SCHEMBL1087914 | 0.73 | CHRM2 (0.47) | CHRM2CHRM3CHRM1CYP2D6CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103717597-B | Heterocyclic compounds as kinase inhibitors | 原真股份有限公司 | 2017-07-04 | — | — | CN | disclosed |
| CN-103492389-B | Pyrazolo [4,3-d] pyrimidine as inhibitors of kinases | 原真股份有限公司 | 2016-09-14 | — | — | CN | disclosed |