Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.67 |
| ▸ | MAPT | P10636 | 4/20 | 0.67 |
| ▸ | LMNA | P02545 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 3/20 | 0.67 |
| ▸ | RAB9A | P51151 | 3/20 | 0.67 |
| ▸ | TP53 | P04637 | 3/20 | 0.67 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.67 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.67 |
| ▸ | RELA | Q04206 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 2/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12834842 | 0.85 | MAPT (0.69) | SMN1; SMN2MAPTLMNANPC1RAB9A | |
| SCHEMBL16359672 | 0.82 | MAPT (0.69) | SMN1; SMN2MAPTLMNANPC1RAB9A | |
| SCHEMBL16358909 | 0.82 | MAPT (0.69) | SMN1; SMN2MAPTLMNANPC1RAB9A | |
| SCHEMBL10789133 | 0.82 | SMN1; SMN2 (0.70) | SMN1; SMN2MAPTLMNANPC1RAB9A | |
| SCHEMBL13303558 | 0.81 | CYP1A2 (0.60) | SMN1; SMN2MAPTLMNANPC1RAB9A | |
| SCHEMBL763447 | 0.81 | ALDH1A1 (0.64) | SMN1; SMN2MAPTLMNANPC1RAB9A | |
| SCHEMBL8995270 | 0.79 | MAPT (0.66) | SMN1; SMN2MAPTLMNANPC1RAB9A | |
| SCHEMBL12835272 | 0.79 | ALDH1A1 (0.62) | SMN1; SMN2MAPTLMNANPC1RAB9A | |
| SCHEMBL8995256 | 0.79 | MAPT (0.66) | SMN1; SMN2MAPTLMNANPC1RAB9A | |
| SCHEMBL24041884 | 0.78 | MAPT (0.72) | SMN1; SMN2MAPTLMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8940896-B2 | Tetra-cyclic carboline derivatives useful in the inhibition of angiogenesis | PTC THERAPEUTICS, INC. (US) | 2015-01-27 | — | — | US | disclosed |