Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.66 |
| ▸ | NPC1 | O15118 | 2/20 | 0.66 |
| ▸ | RAB9A | P51151 | 2/20 | 0.66 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.66 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.66 |
| ▸ | RELA | Q04206 | 1/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16358260 | 0.92 | SMN1; SMN2 (0.72) | MAPTLMNAMEN1KMT2AKDM4E | |
| SCHEMBL10789133 | 0.84 | SMN1; SMN2 (0.70) | MAPTLMNAMEN1KMT2AKDM4E | |
| SCHEMBL12834842 | 0.84 | MAPT (0.69) | MAPTLMNAMEN1KMT2AKDM4E | |
| SCHEMBL8995270 | 0.82 | MAPT (0.66) | MAPTLMNAMEN1KMT2AKDM4E | |
| SCHEMBL16417992 | 0.82 | SMN1; SMN2 (0.67) | MAPTLMNAMEN1KMT2AKDM4E | |
| SCHEMBL8995256 | 0.82 | MAPT (0.66) | MAPTLMNAMEN1KMT2AKDM4E | |
| SCHEMBL763447 | 0.80 | ALDH1A1 (0.64) | MAPTLMNAMEN1KMT2AKDM4E | |
| SCHEMBL16314569 | 0.79 | MAPT (0.62) | MAPTLMNAMEN1KMT2AKDM4E | |
| SCHEMBL12835272 | 0.79 | ALDH1A1 (0.62) | MAPTLMNAMEN1KMT2AKDM4E | |
| SCHEMBL10784148 | 0.76 | SMN1; SMN2 (0.72) | MAPTLMNAMEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732543-B1 | TETRACYCLIC CARBOLINE DERATIVES FOR INHIBITING ANGIOGENESIS | PTC THERAPEUTICS INC (US) | 2017-05-10 | — | — | EP | disclosed |
| WO-2008127715-A1 | CARBOLINE DERIVATIVES USEFUL IN THE TREATMENT OF CANCER AND OTHER DISEASES | PTC THERAPEUTICS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |