Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.47 |
| ▸ | EGLN3 | Q9H6Z9 | 2/20 | 0.47 |
| ▸ | OGFOD1 | Q8N543 | 1/20 | 0.47 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1642058 | 0.98 | OGFOD1 (0.49) | EGLN2EGLN1EGLN3OGFOD1HIF1AN | |
| SCHEMBL1641893 | 0.97 | OGFOD1 (0.51) | EGLN2EGLN1EGLN3OGFOD1HIF1AN | |
| SCHEMBL3420501 | 0.81 | OGFOD1 (0.71) | EGLN2EGLN1EGLN3OGFOD1HIF1AN | |
| SCHEMBL1641163 | 0.81 | ALDH1A1 (0.39) | EGLN2EGLN1EGLN3OGFOD1HIF1AN | |
| SCHEMBL1641120 | 0.80 | HIF1A (0.43) | EGLN1EGLN3ALDH1A1HPGDGLA | |
| Bicarbonate SCHEMBL15419211 | 0.80 | OGFOD1 (0.71) | EGLN2EGLN1EGLN3OGFOD1HIF1AN | |
| SCHEMBL1642547 | 0.77 | HPGD (0.51) | EGLN1ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL3419515 | 0.76 | OGFOD1 (0.65) | EGLN2EGLN1EGLN3OGFOD1HIF1AN | |
| SCHEMBL3419522 | 0.76 | OGFOD1 (0.65) | EGLN2EGLN1EGLN3OGFOD1HIF1AN | |
| SCHEMBL3421368 | 0.75 | OGFOD1 (0.47) | EGLN2EGLN1EGLN3OGFOD1HIF1AN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098324-A1 | PROLYL HYDROXYLASE INHIBITORS | GLAXOSMITHKLINE LLC | 2011-04-28 | — | — | US | disclosed |
| EP-2306828-A1 | PROLYL HYDROXYLASE INHIBITORS | Glaxosmithkline LLC (US) | 2011-04-13 | — | — | EP | disclosed |
| WO-2009158315-A1 | PROLYL HYDROXYLASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-12-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098324-A1 | PROLYL HYDROXYLASE INHIBITORS | HIF1AN, EGLN2, EGLN3 | EGLN2 2/4885EGLN1 6/4885EGLN3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.