Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 19/20 | 0.55 |
| ▸ | ACVR1B | P36896 | 18/20 | 0.55 |
| ▸ | ACVRL1 | P37023 | 16/20 | 0.55 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.47 |
| ▸ | BUB1 | O43683 | 1/20 | 0.46 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3822087 | 0.94 | TGFBR1 (0.55) | TGFBR1ACVR1BACVRL1ACVR1BUB1 | |
| SCHEMBL5954624 | 0.90 | TGFBR1 (0.57) | TGFBR1ACVR1BACVRL1ACVR1BUB1 | |
| SCHEMBL14223120 | 0.90 | TGFBR1 (0.56) | TGFBR1ACVR1BACVRL1ACVR1BUB1 | |
| SCHEMBL5954627 | 0.89 | TGFBR1 (0.57) | TGFBR1ACVR1BACVRL1ACVR1BUB1 | |
| SCHEMBL3829008 | 0.88 | TGFBR1 (0.56) | TGFBR1ACVR1BACVRL1ACVR1BUB1 | |
| SCHEMBL3826786 | 0.88 | TGFBR1 (0.56) | TGFBR1ACVR1BACVRL1ACVR1BUB1 | |
| SCHEMBL5954828 | 0.88 | TGFBR1 (0.60) | TGFBR1ACVR1BACVRL1ACVR1BUB1 | |
| SCHEMBL5955472 | 0.88 | TGFBR1 (0.54) | TGFBR1ACVR1BACVRL1ACVR1BUB1 | |
| SCHEMBL8347338 | 0.86 | TGFBR1 (0.59) | TGFBR1ACVR1BACVRL1ACVR1BUB1 | |
| SCHEMBL5954715 | 0.86 | TGFBR1 (0.58) | TGFBR1ACVR1BACVRL1ACVR1BUB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097084-B1 | CARBOXAMIDE 4-[(4-PYRIDYL)AMINO] PYRIMIDINES FOR THE TREATMENT OF HEPATITIS C | JANSSEN R & D IRELAND (IE) | 2015-01-28 | — | — | EP | disclosed |