Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 19/20 | 0.57 |
| ▸ | ACVR1B | P36896 | 16/20 | 0.57 |
| ▸ | ACVRL1 | P37023 | 14/20 | 0.57 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.48 |
| ▸ | BUB1 | O43683 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3829008 | 0.93 | TGFBR1 (0.56) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL5954627 | 0.92 | TGFBR1 (0.57) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL3826786 | 0.91 | TGFBR1 (0.56) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL14223120 | 0.91 | TGFBR1 (0.56) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL3822087 | 0.90 | TGFBR1 (0.55) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL5955472 | 0.90 | TGFBR1 (0.54) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL16422192 | 0.90 | TGFBR1 (0.55) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL5954491 | 0.89 | TGFBR1 (0.57) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL8348081 | 0.89 | TGFBR1 (0.58) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 | |
| SCHEMBL8347338 | 0.89 | TGFBR1 (0.59) | TGFBR1ACVR1BACVRL1BMPR1AACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060281763-A1 | Carboxamide inhibitors of TGFbeta | SCIOS INC. | 2006-12-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060281763-A1 | Carboxamide inhibitors of TGFbeta | TGFBR1, TGFBR2, TGFB1 | TGFBR1 1/4885ACVR1B 12/4885ACVRL1 39/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.