Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATR | Q13535 | 7/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.46 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.46 |
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | LDHB | P07195 | 1/20 | 0.44 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.44 |
| ▸ | NEK2 | P51955 | 1/20 | 0.44 |
| ▸ | PRKDC | P78527 | 3/20 | 0.44 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16425231 | 0.82 | ATR (0.56) | ATRLDHALDHBNEK2PRKDC | |
| SCHEMBL20371188 | 0.80 | NEK2 (0.56) | ATRHPGDNEK2MAPT | |
| SCHEMBL20987102 | 0.79 | NEK2 (0.48) | ATRIKBKETBK1NEK2ALDH1A1 | |
| SCHEMBL934180 | 0.78 | ATR (0.51) | ATRHPGDNEK2PRKDCALDH1A1 | |
| SCHEMBL481659 | 0.77 | ALOX5AP (0.49) | HPGDIKBKETBK1TLR8ALDH1A1 | |
| SCHEMBL28457228 | 0.76 | KCNH2 (0.62) | ATRNEK2PDGFRBKDR | |
| SCHEMBL29124905 | 0.76 | IKBKE (0.58) | IKBKETBK1ALDH1A1KDM4ECA12 | |
| SCHEMBL23064174 | 0.76 | PIK3CG (0.54) | ATRHPGDPRKDCATMALDH1A1 | |
| SCHEMBL12198422 | 0.76 | ATR (0.48) | ATRHPGDALDH1A1KDM4EMAPT | |
| SCHEMBL1954137 | 0.75 | MAPK1 (0.53) | HPGDIKBKETBK1TLR8ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180194741-A1 | NEW ANTI-MALARIAL AGENTS | UNIVERSITY OF CAPE TOWN (ZA) | 2018-07-12 | — | — | US | disclosed |
| US-9266842-B2 | Anti-malarial agents | MMV MEDICINES FOR MALARIA VENTURE (CH) | 2016-02-23 | — | — | US | disclosed |
| US-20150031682-A1 | ANTI-MALARIAL AGENTS | MMV MEDICINES FOR MALARIA VENTURE (CH) | 2015-01-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150031682-A1 | ANTI-MALARIAL AGENTS | QDPR, DHFR, IL5 | ATR 4093/4885HPGD 708/4885IKBKE 2437/4885 |
| US-20180194741-A1 | NEW ANTI-MALARIAL AGENTS | QDPR, API5, DHFR | ATR 4067/4885HPGD 713/4885IKBKE 1931/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.