Pseudolaric Acid B

Pseudolaric Acid B

SCHEMBL16426061

COC(=O)C1=CC[C@@]23CC[C@@H]([C@@](C)(/C=C/C=C(\C)C(=O)O)OC2=O)[C@@]3(OC(C)=O)CC1

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ BSG P35613 1/20 0.58
▸ CRBN Q96SW2 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pseudolaric Acid B SCHEMBL29357444 1.00 BSG (0.58) BSGCRBN
Pseudolaric Acid B SCHEMBL29367226 1.00 BSG (0.58) BSGCRBN
Pseudolaric Acid A SCHEMBL29785336 0.88 BSG (0.47) BSGCRBN
Pseudolaric Acid A SCHEMBL27964349 0.88 BSG (0.47) BSGCRBN
Pseudolaric Acid C SCHEMBL29754805 0.87 BSG (0.46) BSGCRBN
Pseudolaric Acid C SCHEMBL28774868 0.87 BSG (0.46) BSGCRBN
SCHEMBL28845305 0.86 BSG (0.45) BSGCRBN
SCHEMBL18561099 0.77 BSG (0.47) BSGCRBN
SCHEMBL16429224 0.74 BSG (0.37) BSGCRBN
SCHEMBL8255709 0.57 CHRM3 (0.38) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10960078-B2 Amphiphilic drug-drug conjugates for cancer therapy, compositions and methods of preparation and uses thereof SHANGHAI JIAO TONG UNIVERSITY (CN) 2021-03-30 — — US disclosed
US-10463743-B2 Amphiphilic drug-drug conjugates for cancer therapy, compositions and methods of preparation and uses thereof SHANGHAI JIAO TONG UNIVERSITY (CN) 2019-11-05 — — US disclosed
US-20170056506-A1 AMPHIPHILIC DRUG-DRUG CONJUGATES FOR CANCER THERAPY, COMPOSITIONS AND METHODS OF PREPARATION AND USES THEREOF UNIV SHANGHAI JIAOTONG (CN) 2017-03-02 — — US disclosed
US-20170056506-A1 AMPHIPHILIC DRUG-DRUG CONJUGATES FOR CANCER THERAPY, COMPOSITIONS AND METHODS OF PREPARATION AND USES THEREOF UNIV SHANGHAI JIAOTONG (CN) 2017-03-02 — — US disclosed
US-9533054-B2 Amphiphilic drug-drug conjugates for cancer therapy, compositions and methods of preparation and uses thereof SHANGHAI JIAO TONG UNIVERSITY (CN) 2017-01-03 — — US disclosed
US-20150031644-A1 AMPHIPHILIC DRUG-DRUG CONJUGATES FOR CANCER THERAPY, COMPOSITIONS AND METHODS OF PREPARATION AND USES THEREOF UNIV SHANGHAI JIAOTONG (CN) 2015-01-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170056506-A1 AMPHIPHILIC DRUG-DRUG CONJUGATES FOR CANCER THERAPY, COMPOSITIONS AND METHODS OF PREPARATION AND USES THEREOF ABCB4, ABCB1, LCAT BSG 218/4885CRBN 2085/4885
US-10463743-B2 Amphiphilic drug-drug conjugates for cancer therapy, compositions and methods of preparation and uses thereof ABCB4, ABCB1, LCAT BSG 218/4885CRBN 2085/4885
US-10960078-B2 Amphiphilic drug-drug conjugates for cancer therapy, compositions and methods of preparation and uses thereof ABCB4, ABCB1, LCAT BSG 218/4885CRBN 2085/4885
US-20150031644-A1 AMPHIPHILIC DRUG-DRUG CONJUGATES FOR CANCER THERAPY, COMPOSITIONS AND METHODS OF PREPARATION AND USES THEREOF ABCB4, ABCB1, LCAT BSG 218/4885CRBN 2085/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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