Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CXCR1 | P25024 | 6/20 | 0.48 |
| ▸ | CXCR2 | P25025 | 6/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL168202 | 0.85 | NPC1 (0.49) | ALDH1A1CXCR1CXCR2POLBKMT2A | |
| SCHEMBL167754 | 0.81 | KMT2A (0.46) | ALDH1A1POLBKMT2ANPC1RAB9A | |
| SCHEMBL16451197 | 0.75 | HCAR2 (0.40) | ALDH1A1POLBKMT2AMAPTMEN1 | |
| SCHEMBL953263 | 0.74 | CDK2 (0.54) | ALDH1A1POLBKMT2ANPC1RAB9A | |
| SCHEMBL956114 | 0.74 | CCNA2 (0.56) | ALDH1A1POLBKMT2ANPC1RAB9A | |
| SCHEMBL8221792 | 0.72 | RAB9A (0.51) | POLBRAB9AMAPTGAASMN1; SMN2 | |
| SCHEMBL4564408 | 0.72 | ALDH1A1 (0.47) | ALDH1A1POLBKMT2ANPC1RAB9A | |
| SCHEMBL959184 | 0.72 | CDK2 (0.58) | ALDH1A1CXCR1CXCR2POLBKMT2A | |
| SCHEMBL954483 | 0.72 | KMT2A (0.45) | ALDH1A1CXCR1CXCR2POLBKMT2A | |
| SCHEMBL956175 | 0.72 | POLB (0.46) | ALDH1A1CXCR1CXCR2POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609091-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | Lead Discovery Center GmbH (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012028332-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |