Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1328169 | 0.71 | GCK (1.00) | GCKHPGDALDH1A1GAASCN9A | |
| SCHEMBL1329252 | 0.71 | GCK (0.69) | GCKHPGDALDH1A1NPC1RAB9A | |
| SCHEMBL12126257 | 0.67 | GCK (0.63) | GCKHPGDALDH1A1NPC1RAB9A | |
| SCHEMBL1329540 | 0.65 | GCK (0.48) | GCKALDH1A1NPC1RAB9APOLB | |
| SCHEMBL7054403 | 0.64 | GAA (0.64) | GCKHPGDALDH1A1SMN1; SMN2POLB | |
| SCHEMBL28242322 | 0.64 | GAA (0.51) | GCKHPGDALDH1A1SMN1; SMN2POLB | |
| SCHEMBL8431375 | 0.63 | GAA (0.62) | GCKALDH1A1SMN1; SMN2POLBGAA | |
| SCHEMBL16429528 | 0.62 | GRM5 (0.34) | GCKALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL28625665 | 0.62 | AR (0.61) | GCKNPC1RAB9ASMN1; SMN2POLB | |
| SCHEMBL7108791 | 0.61 | MAP4K4 (0.52) | GCKHPGDALDH1A1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2543667-B1 | A method of preparing 2-aminopyridine analogs as glucokinase activators | ARRAY BIOPHARMA INC (US) | 2015-01-28 | — | — | EP | disclosed |