Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | PRKDC | P78527 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20562664 | 0.83 | TDP1 (0.37) | MAPTRAB9ANPC1HPGDLMNA | |
| SCHEMBL16964337 | 0.79 | MAPT (0.49) | MAPTRAB9ANPC1HPGDLMNA | |
| SCHEMBL3904650 | 0.79 | RAB9A (0.41) | MAPTRAB9ANPC1LMNAPRKDC | |
| SCHEMBL9181673 | 0.79 | ALDH1A1 (0.41) | MAPTHPGDLMNAPRKDCSMN1; SMN2 | |
| SCHEMBL2315135 | 0.79 | MAPT (0.41) | MAPTRAB9ANPC1LMNAPRKDC | |
| SCHEMBL23702335 | 0.79 | AR (0.41) | MAPTRAB9ANPC1HPGDLMNA | |
| SCHEMBL17376437 | 0.77 | PIK3CA (0.37) | PRKDCRXFP1 | |
| SCHEMBL25292038 | 0.75 | PRKDC (0.41) | MAPTRAB9ANPC1HPGDLMNA | |
| SCHEMBL15391006 | 0.75 | PRKDC (0.44) | MAPTRAB9ANPC1HPGDPRKDC | |
| SCHEMBL23702338 | 0.75 | AR (0.42) | MAPTHPGDLMNAPRKDCSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104350055-B | Bicyclic heteroaryl derivatives and application thereof as MNK1 and MNK2 regulator | 新加坡科技研究局 | 2019-05-31 | — | — | CN | disclosed |
| US-10280168-B2 | Bicyclic heteroaryl derivatives as MNK1 and MNK2 modulators and uses thereof | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2019-05-07 | — | — | US | disclosed |
| CN-104350055-A | Bicyclic heterocyclic derivatives as MNK1 and MNK2 modulators and uses thereof | AGENCY SCIENCE TECH & RES (SG) | 2015-02-11 | — | — | CN | disclosed |
| US-20150038506-A1 | BICYCLIC HETEROARYL DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2015-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10280168-B2 | Bicyclic heteroaryl derivatives as MNK1 and MNK2 modulators and uses thereof | MAPKAPK2, NEK2, MKNK2 | MAPT 674/4885RAB9A 1936/4885NPC1 2469/4885 |
| US-20150038506-A1 | BICYCLIC HETEROARYL DERIVATIVES AS MNK1 AND MNK2 MODULATORS AND USES THEREOF | MAPKAPK2, NEK2, MKNK2 | MAPT 680/4885RAB9A 1906/4885NPC1 2480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.