Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8508145 | 0.77 | MAPT (0.42) | KMT2AALDH1A1MEN1CYP1A2CYP2C9 | |
| SCHEMBL6452853 | 0.73 | KMT2A (0.44) | KMT2AALDH1A1MEN1CYP1A2CYP2C9 | |
| SCHEMBL5069466 | 0.73 | KMT2A (0.47) | KMT2AALDH1A1MEN1CYP1A2CYP2C9 | |
| SCHEMBL252506 | 0.70 | ALDH1A1 (0.51) | KMT2AALDH1A1MEN1CYP1A2CYP2C9 | |
| SCHEMBL6845223 | 0.70 | ALDH1A1 (0.51) | KMT2AALDH1A1MEN1CYP1A2CYP2C9 | |
| SCHEMBL5071027 | 0.70 | ALDH1A1 (0.43) | KMT2AALDH1A1MEN1CYP1A2CYP2C19 | |
| SCHEMBL14661902 | 0.70 | NPC1 (0.40) | KMT2AALDH1A1MEN1CYP1A2CYP2C9 | |
| SCHEMBL7418666 | 0.69 | HDAC3 (0.55) | KMT2AMEN1L3MBTL1 | |
| SCHEMBL28041200 | 0.69 | TDP1 (0.50) | KMT2AALDH1A1MEN1CYP2C19MAPT | |
| SCHEMBL13866308 | 0.69 | CHRNA7 (0.46) | KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3027601-A1 | SYK INHIBITORS | Gilead Sciences, Inc. (US) | 2016-06-08 | — | — | EP | disclosed |
| WO-2015017610-A1 | SYK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2015-02-05 | — | — | WO | disclosed |