Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 3/20 | 0.55 |
| ▸ | EGFR | P00533 | 8/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 7/20 | 0.48 |
| ▸ | ERBB3 | P21860 | 7/20 | 0.48 |
| ▸ | ERBB4 | Q15303 | 7/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.45 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.45 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | TEK | Q02763 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16432224 | 0.82 | ERBB2 (0.46) | TRPA1EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL16432121 | 0.79 | EGFR (0.71) | EGFRERBB2ERBB3ERBB4TTBK1 | |
| SCHEMBL16433189 | 0.77 | LTA4H (0.44) | TRPA1EGFRKDRTEKTSHR | |
| SCHEMBL4001800 | 0.75 | CDC7 (0.60) | EGFRERBB2ERBB3ERBB4DYRK1A | |
| SCHEMBL4290591 | 0.75 | DYRK1A (0.45) | TRPA1EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL15612939 | 0.73 | DYRK1A (0.53) | TRPA1EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL6435658 | 0.71 | ERBB2 (0.47) | TRPA1EGFRERBB2ERBB3ERBB4 | |
| SCHEMBL2748271 | 0.71 | MEN1 (0.43) | TRPA1EGFRKDRTSHRNPC1 | |
| SCHEMBL3979754 | 0.69 | EGFR (0.69) | TRPA1EGFRKDRTEKTSHR | |
| SCHEMBL252692 | 0.68 | TRPA1 (0.58) | TRPA1EGFRTSHRNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105814057-B | Pyrimidines, pyridines and pyrazines as BTK inhibitors and uses thereof | 默克专利有限公司 | 2019-05-03 | — | — | CN | disclosed |
| EP-3049417-B1 | PYRIDINES, PYRIMIDINES, AND PYRAZINES, AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2018-10-17 | — | — | EP | disclosed |
| US-10005784-B2 | Pyridines, pyrimidines, and pyrazines, as BTK inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2018-06-26 | — | — | US | disclosed |
| US-10005784-B2 | Pyridines, pyrimidines, and pyrazines, as BTK inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2018-06-26 | — | — | US | disclosed |
| US-9738648-B2 | Pyridines, pyrimidines, and pyrazines, as BTK inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2017-08-22 | — | — | US | disclosed |
| US-9738648-B2 | Pyridines, pyrimidines, and pyrazines, as BTK inhibitors and uses thereof | MERCK PATENT GMBH (DE) | 2017-08-22 | — | — | US | disclosed |
| US-20170226113-A1 | PYRIDINES, PYRIMIDINES, AND PYRAZINES, AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2017-08-10 | — | — | US | disclosed |
| US-20170226113-A1 | PYRIDINES, PYRIMIDINES, AND PYRAZINES, AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2017-08-10 | — | — | US | disclosed |
| EP-3049417-A1 | PYRIDINES, PYRIMIDINES, AND PYRAZINES, AS BTK INHIBITORS AND USES THEREOF | Merck Patent GmbH (DE) | 2016-08-03 | — | — | EP | disclosed |
| CN-105814057-A | Pyrimidines, pyridines and pyrazines as BTK inhibitors and uses thereof | 默克专利有限公司 | 2016-07-27 | — | — | CN | disclosed |
| US-20160159804-A1 | PYRIDINES, PYRIMIDINES, AND PYRAZINES, AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2016-06-09 | — | — | US | disclosed |
| US-20160159804-A1 | PYRIDINES, PYRIMIDINES, AND PYRAZINES, AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2016-06-09 | — | — | US | disclosed |
| WO-2015017502-A1 | PYRIDINES, PYRIMIDINES, AND PYRAZINES, AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2015-02-05 | — | — | WO | disclosed |
| WO-2015017502-A1 | PYRIDINES, PYRIMIDINES, AND PYRAZINES, AS BTK INHIBITORS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2015-02-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170226113-A1 | PYRIDINES, PYRIMIDINES, AND PYRAZINES, AS BTK INHIBITORS AND USES THEREOF | BTK, SYK, LYN | TRPA1 1872/4885EGFR 1018/4885ERBB2 139/4885 |
| US-20160159804-A1 | PYRIDINES, PYRIMIDINES, AND PYRAZINES, AS BTK INHIBITORS AND USES THEREOF | BTK, SYK, LYN | TRPA1 1872/4885EGFR 1018/4885ERBB2 139/4885 |
| US-10005784-B2 | Pyridines, pyrimidines, and pyrazines, as BTK inhibitors and uses thereof | BTK, SYK, LYN | TRPA1 2180/4885EGFR 1046/4885ERBB2 143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.