Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Diethylamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1726899 | 0.84 | — | — | |
| SCHEMBL27847630 | 0.82 | MAPT (0.31) | LMNAHPGDMEN1KMT2A | |
| Ammonia Solution, Strong SCHEMBL4593126 | 0.82 | MAPT (0.31) | LMNAHPGDMEN1KMT2A | |
| Benzene SCHEMBL9706847 | 0.77 | SMN1; SMN2 (0.38) | LMNAHPGDMEN1KMT2A | |
| Diethylamine SCHEMBL2064180 | 0.76 | TP53 (0.57) | LMNAHPGDHIF1AHSD17B10TP53 | |
| Diethylamine SCHEMBL28166068 | 0.76 | TP53 (0.57) | LMNAHPGDHIF1AHSD17B10TP53 | |
| Diethylamine SCHEMBL2064182 | 0.76 | TP53 (0.57) | LMNAHPGDHIF1AHSD17B10TP53 | |
| Diethylamine SCHEMBL4255966 | 0.76 | TP53 (0.57) | LMNAHPGDHIF1AHSD17B10TP53 | |
| Diethylamine SCHEMBL7907061 | 0.73 | TP53 (0.53) | LMNAHPGDHIF1AHSD17B10TP53 | |
| Diethylamine SCHEMBL28330882 | 0.73 | TP53 (0.53) | LMNAHPGDHIF1AHSD17B10TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3027769-A1 | COMPOSITIONS AND METHODS FOR BISULFITE CONVERTED SEQUENCE CAPTURE | F. Hoffmann-La Roche AG (CH) | 2016-06-08 | — | — | EP | disclosed |
| WO-2015014759-A1 | COMPOSITIONS AND METHODS FOR BISULFITE CONVERTED SEQUENCE CAPTURE | F. HOFFMANN-LA ROCHE AG (CH) | 2015-02-05 | — | — | WO | disclosed |