Amicibone

Amicibone

SCHEMBL1643546

O=C1CCCCC1(CCN1CCCCCC1)C(=O)OCc1ccccc1

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAPK1 P28482 1/20 0.46
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
SMN1; SMN2 Q16637 2/20 0.43
GAA P10253 1/20 0.43
DDB1 Q16531 1/20 0.43
CRBN Q96SW2 1/20 0.43
EGFR P00533 2/20 0.42
KDM4E B2RXH2 2/20 0.42
ALDH1A1 P00352 1/20 0.42
NPY1R P25929 1/20 0.42
HRH3 Q9Y5N1 1/20 0.42
HTT P42858 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Amicibone SCHEMBL317245 0.99 MAPK1 (0.47) MAPK1MEN1KMT2ANPC1RAB9A
SCHEMBL3696556 0.80 DDB1 (0.49) DDB1CRBN
SCHEMBL3776600 0.79 DDB1 (0.46) KMT2ADDB1CRBNALDH1A1
SCHEMBL3789659 0.77 DDB1 (0.46) MAPK1SMN1; SMN2DDB1CRBNHTT
SCHEMBL3788196 0.72 DDB1 (0.42) NPC1RAB9ASMN1; SMN2GAADDB1
SCHEMBL5319955 0.72 DDB1 (0.51) DDB1CRBNALDH1A1
SCHEMBL2125064 0.72 DDB1 (0.54) DDB1CRBNALDH1A1
SCHEMBL10801425 0.72 DDB1 (0.41) MEN1KMT2ASMN1; SMN2DDB1CRBN
SCHEMBL8569113 0.71 ALDH1A1 (0.42) MAPK1SMN1; SMN2DDB1CRBNKDM4E
SCHEMBL14537683 0.71 DDB1 (0.50) DDB1CRBNALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 126 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1651184-B1 FAST DISSOLVING ORALLY CONSUMABLE FILMS CONTAINING PHARMACEUTICALLY ACTIVE AGENTS MCNEIL PPC INC (US) 2013-05-22 EP claimed
EP-1651184-A1 FAST DISSOLVING ORALLY CONSUMABLE FILMS CONTAINING PHARMACEUTICALLY ACTIVE AGENTS Warner-Lambert Company LLC (US) 2006-05-03 EP claimed
CN-1750809-A Fast dissolving orally consumable films containing pharmaceutically active agents WARNER LAMBERT CO (US) 2006-03-22 CN claimed
WO-2004096174-A1 FAST DISSOLVING ORALLY CONSUMABLE FILMS CONTAINING PHARMACEUTICALLY ACTIVE AGENTS WARNER-LAMBERT COMPANY LLC (US) 2004-11-11 WO claimed
US-20030206942-A1 Fast dissolving orally consumable films containing an antitussive and a mucosa coating agent MCNEIL-PPC, INC 2003-11-06 US claimed
EP-1336602-A1 Nitrate prodrugs able to release nitric oxide in a controlled and selective way and their use for prevention and treatment of inflammatory, ischemic and proliferative diseases Scaramuzzino, Giovanni (IT) 2003-08-20 EP claimed
CN-1294519-A Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient INPHARMA SA (CH) 2001-05-09 CN claimed
EP-1073470-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2001-02-07 EP claimed
WO-2000048636-A1 PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS INPHARMA S.A. (CH) 2000-08-24 WO claimed
US-20200197310-A1 Technology for Preparation of Macromolecular Microspheres NEXBIO, INC. 2020-06-25 US disclosed
US-10583086-B2 Technology for preparation of macromolecular microspheres ANSUN BIOPHARMA, INC. (US) 2020-03-10 US disclosed
US-10231938-B2 Transdermal drug delivery device including an occlusive backing NOVEN PHARMACEUTICALS, INC. (US) 2019-03-19 US disclosed
US-20180071219-A1 Technology for Preparation of Macromolecular Microspheres NEXBIO, INC. 2018-03-15 US disclosed
US-20180028449-A1 Technology for the Preparation of Microparticles NEXBIO, INC. 2018-02-01 US disclosed
WO-1999015210-A2 BIOADHESIVE COMPOSITIONS AND METHODS FOR TOPICAL ADMINISTRATION OF ACTIVE AGENTS NOVEN PHARMACEUTICALS, INC. (US) 1999-04-01 WO disclosed
US-5719197-A DRUG DELIVERY NOVEN PHARMACEUTICALS, INC. (US) 1998-02-17 US disclosed
US-5656286-A BLEND OF TWO POLYMERS; PRESSURE SENSITIVE ADHESIVE NOVEN PHARMACEUTICALS, INC. (US) 1997-08-12 US disclosed
WO-1996040084-A1 COMPOSITIONS AND METHODS FOR USE OF PRESSURE SENSITIVE ADHESIVE TRANSDERMAL DEVICES CONTAINING A BIOADHESIVE HUMECTANT NOVEN PHARMACEUTICALS, INC. (US) 1996-12-19 WO disclosed
WO-1996040086-A2 COMPOSITIONS AND METHODS FOR TOPICAL ADMINISTRATION OF PHARMACEUTICALLY ACTIVE AGENTS NOVEN PHARMACEUTICALS, INC. (US) 1996-12-19 WO disclosed
US-5446070-A Flexible, finite, bioadhesive, therapeutical agent in solid form NOVER PHARMACEUTICALS, INC. (US) 1995-08-29 US disclosed