Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16437241 | 0.87 | SMPD3 (0.36) | SMN1; SMN2MEN1KMT2ALMNAPOLB | |
| SCHEMBL16437283 | 0.86 | ALDH1A1 (0.53) | SMN1; SMN2MEN1KMT2ALMNAPOLB | |
| SCHEMBL25678730 | 0.84 | FGFR3 (0.47) | SMN1; SMN2ALDH1A1DRD2DRD3ADRA1D | |
| SCHEMBL16440187 | 0.83 | ALDH1A1 (0.43) | SMN1; SMN2LMNAALDH1A1DRD2DRD3 | |
| SCHEMBL25678780 | 0.82 | FLT3 (0.42) | ALDH1A1DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL20934843 | 0.82 | DRD2 (0.48) | ALDH1A1DRD2DRD3ADRA1DADRA1A | |
| SCHEMBL15540550 | 0.82 | NR4A1 (0.46) | SMN1; SMN2ALDH1A1DRD2DRD3ADRA1D | |
| SCHEMBL16437233 | 0.81 | MEN1 (0.35) | SMN1; SMN2MEN1KMT2ALMNAPOLB | |
| SCHEMBL25678778 | 0.81 | FGFR3 (0.49) | SMN1; SMN2ALDH1A1DRD2DRD3 | |
| SCHEMBL13624056 | 0.81 | TNIK (0.47) | SMN1; SMN2MEN1KMT2ALMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10005774-B2 | Syk inhibitors | GILEAD SCIENCES, INC. (US) | 2018-06-26 | — | — | US | disclosed |
| US-10005774-B2 | Syk inhibitors | GILEAD SCIENCES, INC. (US) | 2018-06-26 | — | — | US | disclosed |
| US-20160368918-A1 | SYK INHIBITORS | Kronos Bio, Inc. | 2016-12-22 | — | — | US | disclosed |
| US-9376441-B2 | Substituted pyrrolidines as SYK inhibitors | GILEAD SCIENCES, INC. (US) | 2016-06-28 | — | — | US | disclosed |
| US-20150038488-A1 | SYK INHIBITORS | Kronos Bio, Inc. | 2015-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038488-A1 | SYK INHIBITORS | SYK, BTK, LYN | SMN1; SMN2 3200/4885MEN1 3234/4885KMT2A 850/4885 |
| US-20160368918-A1 | SYK INHIBITORS | SYK, BTK, LYN | SMN1; SMN2 3271/4885MEN1 3190/4885KMT2A 930/4885 |
| US-10005774-B2 | Syk inhibitors | SYK, BTK, LYN | SMN1; SMN2 3271/4885MEN1 3190/4885KMT2A 930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.