Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.55 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.53 |
| ▸ | CCR1 | P32246 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.49 |
| ▸ | WNT3A | P56704 | 2/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16427211 | 0.85 | PDE4D (0.50) | PDE4DPDE4BPOLBCTNNB1WNT3A | |
| SCHEMBL16427380 | 0.84 | PDE4D (0.52) | PDE4DPDE4BPOLBCTNNB1WNT3A | |
| SCHEMBL16437438 | 0.79 | PDE4B (0.52) | PDE4DPDE4BPOLBCTNNB1WNT3A | |
| SCHEMBL16426583 | 0.77 | PDE4B (0.50) | PDE4BPOLBCTNNB1WNT3ACYP2C19 | |
| SCHEMBL19498643 | 0.76 | CA12 (0.51) | PDE4DPDE4BPOLBCTNNB1WNT3A | |
| SCHEMBL16437437 | 0.76 | PDE4B (0.51) | PDE4DPDE4BPOLBCTNNB1WNT3A | |
| SCHEMBL16437443 | 0.76 | PDE4B (0.48) | PDE4DPDE4BPOLBCTNNB1WNT3A | |
| SCHEMBL28058790 | 0.76 | PDE4B (0.48) | PDE4DPDE4BPOLBCTNNB1WNT3A | |
| SCHEMBL16426964 | 0.75 | PDE4B (0.48) | PDE4BPOLBCTNNB1WNT3ACYP2C19 | |
| SCHEMBL16427745 | 0.75 | PDE4B (0.50) | PDE4DPDE4BPOLBCTNNB1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10005774-B2 | Syk inhibitors | GILEAD SCIENCES, INC. (US) | 2018-06-26 | — | — | US | disclosed |
| US-20160368918-A1 | SYK INHIBITORS | Kronos Bio, Inc. | 2016-12-22 | — | — | US | disclosed |
| US-9376441-B2 | Substituted pyrrolidines as SYK inhibitors | GILEAD SCIENCES, INC. (US) | 2016-06-28 | — | — | US | disclosed |
| US-20150038488-A1 | SYK INHIBITORS | Kronos Bio, Inc. | 2015-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038488-A1 | SYK INHIBITORS | SYK, BTK, LYN | PDE4D 1210/4885PDE4B 1658/4885CCR1 1205/4885 |
| US-20160368918-A1 | SYK INHIBITORS | SYK, BTK, LYN | PDE4D 1290/4885PDE4B 1728/4885CCR1 1251/4885 |
| US-10005774-B2 | Syk inhibitors | SYK, BTK, LYN | PDE4D 1290/4885PDE4B 1728/4885CCR1 1251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.