Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | TPMT | P51580 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16426964 | 0.87 | PDE4B (0.48) | PDE4BHSD11B1SMN1; SMN2CYP2C19MAPT | |
| SCHEMBL16437443 | 0.83 | PDE4B (0.48) | PDE4BHSD11B1SMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL16426583 | 0.78 | PDE4B (0.50) | PDE4BHSD11B1CYP2C19MAPTALDH1A1 | |
| SCHEMBL16427380 | 0.78 | PDE4D (0.52) | PDE4BHSD11B1SMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL19498643 | 0.77 | CA12 (0.51) | PDE4BCA12CA1CA2CA4 | |
| SCHEMBL16427211 | 0.76 | PDE4D (0.50) | PDE4BHSD11B1SMN1; SMN2CYP2C19PDE4D | |
| SCHEMBL16437441 | 0.76 | PDE4D (0.55) | PDE4BHSD11B1SMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL16437438 | 0.75 | PDE4B (0.52) | PDE4BHSD11B1CYP3A4CYP2C19CYP2C9 | |
| SCHEMBL16437437 | 0.72 | PDE4B (0.51) | PDE4BCA12CA1CA2CA4 | |
| SCHEMBL16437442 | 0.68 | PDE4B (0.53) | PDE4BSMN1; SMN2CYP3A4CYP2C19CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105555780-A | Syk inhibitors | GILEAD SCIENCES INC | 2016-05-04 | — | — | CN | disclosed |