Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CA4 | P22748 | 1/20 | 0.51 |
| ▸ | CA6 | P23280 | 1/20 | 0.51 |
| ▸ | CA7 | P43166 | 1/20 | 0.51 |
| ▸ | TPMT | P51580 | 1/20 | 0.51 |
| ▸ | CA9 | Q16790 | 1/20 | 0.51 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | CBX7 | O95931 | 3/20 | 0.47 |
| ▸ | CDYL2 | Q8N8U2 | 3/20 | 0.47 |
| ▸ | CDYL | Q9Y232 | 3/20 | 0.47 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 3/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16427745 | 0.85 | PDE4B (0.50) | PDE4BCYP2C19CBX7CDYL2CDYL | |
| SCHEMBL16437437 | 0.82 | PDE4B (0.51) | CA12CA1CA2CA4CA6 | |
| SCHEMBL28058790 | 0.77 | PDE4B (0.48) | CA12CA1CA2CA4CA6 | |
| SCHEMBL16437441 | 0.76 | PDE4D (0.55) | PDE4BCYP3A4CYP2C19CYP2C9PDE4D | |
| SCHEMBL16427380 | 0.73 | PDE4D (0.52) | PDE4BCYP3A4CYP2C19CYP2C9PDE4D | |
| SCHEMBL16437438 | 0.72 | PDE4B (0.52) | PDE4BCYP3A4CYP2C19CYP2C9CBX7 | |
| SCHEMBL16437443 | 0.72 | PDE4B (0.48) | PDE4BCYP3A4CYP2C19CYP2C9CBX7 | |
| SCHEMBL16427211 | 0.72 | PDE4D (0.50) | PDE4BCYP2C19PDE4DMAPTTSHR | |
| SCHEMBL16437442 | 0.71 | PDE4B (0.53) | PDE4BCYP3A4CYP2C19CYP2C9MAPT | |
| SCHEMBL16426583 | 0.71 | PDE4B (0.50) | PDE4BCYP2C19MAPTTSHRCTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105555780-B | SYK inhibitors | 吉利德科学公司 | 2018-01-23 | — | — | CN | disclosed |
| EP-3027601-B1 | SYK INHIBITORS | GILEAD SCIENCES INC (US) | 2017-10-25 | — | — | EP | disclosed |
| CN-105555780-A | Syk inhibitors | GILEAD SCIENCES INC | 2016-05-04 | — | — | CN | disclosed |