Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.47 |
| ▸ | DPP4 | P27487 | 2/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | SUV39H2 | Q9H5I1 | 8/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24123755 | 0.91 | ALDH1A1 (0.43) | SMPD3DPP4ADRA1ASUV39H2ACHE | |
| SCHEMBL5395255 | 0.85 | NR4A1 (0.49) | SMPD3ADRA1DADRA1BADRA1ASUV39H2 | |
| SCHEMBL16440156 | 0.83 | ALDH1A1 (0.44) | DPP4ADRA1AACHEMEN1POLB | |
| SCHEMBL15382192 | 0.82 | SMPD3 (0.47) | SMPD3DPP4SUV39H2ACHEKEAP1 | |
| SCHEMBL16437252 | 0.82 | SMPD3 (0.42) | SMPD3ADRA1DADRA1BADRA1ASUV39H2 | |
| SCHEMBL29994839 | 0.80 | DRD2 (0.54) | ADRA1DADRA1BADRA1AALDH1A1 | |
| SCHEMBL17376186 | 0.80 | DRD2 (0.54) | ADRA1DADRA1BADRA1AALDH1A1 | |
| SCHEMBL24123881 | 0.80 | KCNH2 (0.43) | DPP4SUV39H2ACHEKEAP1ALDH1A1 | |
| SCHEMBL13419301 | 0.79 | ACACB (0.45) | KMT2AALDH1A1HRH4 | |
| SCHEMBL12362773 | 0.79 | ALDH1A1 (0.43) | SMPD3SUV39H2ACHEKEAP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3027601-B1 | SYK INHIBITORS | GILEAD SCIENCES INC (US) | 2017-10-25 | — | — | EP | disclosed |
| US-20160368918-A1 | SYK INHIBITORS | Kronos Bio, Inc. | 2016-12-22 | — | — | US | disclosed |
| US-9376441-B2 | Substituted pyrrolidines as SYK inhibitors | GILEAD SCIENCES, INC. (US) | 2016-06-28 | — | — | US | disclosed |
| US-20150038488-A1 | SYK INHIBITORS | Kronos Bio, Inc. | 2015-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038488-A1 | SYK INHIBITORS | SYK, BTK, LYN | SMPD3 701/4885DPP4 3377/4885ADRA1D 3304/4885 |
| US-20160368918-A1 | SYK INHIBITORS | SYK, BTK, LYN | SMPD3 689/4885DPP4 3370/4885ADRA1D 3418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.