Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCNN1A | P37088 | 12/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL16443777 | 1.00 | SCNN1A (0.54) | SCNN1AKCNH2 | |
| Hydrochloric Acid SCHEMBL16443778 | 1.00 | SCNN1A (0.54) | SCNN1AKCNH2 | |
| SCHEMBL16453284 | 0.99 | SCNN1A (0.54) | SCNN1AKCNH2 | |
| SCHEMBL20683800 | 0.99 | SCNN1A (0.54) | SCNN1AKCNH2 | |
| SCHEMBL16443694 | 0.92 | SCNN1A (0.54) | SCNN1AKCNH2 | |
| SCHEMBL16443693 | 0.92 | SCNN1A (0.54) | SCNN1AKCNH2 | |
| SCHEMBL16443691 | 0.92 | SCNN1A (0.54) | SCNN1AKCNH2 | |
| SCHEMBL20683787 | 0.88 | SCNN1A (0.50) | SCNN1AKCNH2 | |
| Hydrochloric Acid SCHEMBL20677538 | 0.88 | SCNN1A (0.57) | SCNN1AKCNH2 | |
| Hydrochloric Acid SCHEMBL20677537 | 0.88 | SCNN1A (0.57) | SCNN1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3030555-B1 | NOVEL PYRAZINE AMIDE COMPOUNDS | BOEHRINGER INGELHEIM INT (DE) | 2019-01-30 | — | — | EP | disclosed |
| EP-3030555-A1 | NOVEL PYRAZINE AMIDE COMPOUNDS | Boehringer Ingelheim International GmbH (DE) | 2016-06-15 | — | — | EP | disclosed |
| US-9096548-B2 | Pyrazine amide compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-08-04 | — | — | US | disclosed |
| WO-2015018754-A1 | NOVEL PYRAZINE AMIDE COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-12 | — | — | WO | disclosed |
| US-20150045326-A1 | NOVEL PYRAZINE AMIDE COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2015-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150045326-A1 | NOVEL PYRAZINE AMIDE COMPOUNDS | HRH4, HRH1, HRH2 | SCNN1A 285/4885KCNH2 221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.