Cytosine

Cytosine

SCHEMBL16447233

Nc1cc[nH]c(=O)n1.Nc1ccn(CO)c(=O)n1

nearest known ligand 0.42

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 4/20 0.42
SLC22A6 Q4U2R8 1/20 0.41
LMNA P02545 3/20 0.36
THRB P10828 1/20 0.36
MTOR P42345 1/20 0.36
MDM2 Q00987 1/20 0.36
NCOA1 Q15788 1/20 0.36
NCOA3 Q9Y6Q9 1/20 0.36
PDE3A Q14432 3/20 0.35
CACNA1F O60840 2/20 0.35
ALB P02768 2/20 0.35
MAPT P10636 2/20 0.35
CACNA1D Q01668 2/20 0.35
CACNA1S Q13698 2/20 0.35
CACNA1C Q13936 2/20 0.35
PDE4D Q08499 1/20 0.34
SLC29A1 Q99808 1/20 0.34
EP300 Q09472 7/20 0.33
CYP2D6 P10635 1/20 0.33
DNMT1 P26358 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL236000 0.86 FGFR1 (0.51) FGFR1SLC22A6LMNATHRBMTOR
Phosphoric Acid SCHEMBL27689268 0.80 FGFR1 (0.57) FGFR1SLC22A6LMNATHRBMTOR
Cytosine SCHEMBL1576155 0.79 DYRK1A (0.38) MAPT
Cytosine SCHEMBL1673111 0.77 BRD4 (0.40) LMNATHRBMTORMDM2NCOA1
Cytosine SCHEMBL4059 0.77
Cytosine SCHEMBL1330400 0.77
Cytosine SCHEMBL4657334 0.77 DYRK1A (0.44) MAPT
Cytosine SCHEMBL1330710 0.77
Cytosine SCHEMBL6839378 0.75 NOTUM (0.34) LMNATHRBMTORMDM2NCOA1
SCHEMBL16446911 0.75 FGFR1 (0.47) FGFR1SLC22A6LMNATHRBMTOR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160177381-A1 Base-Pair Specific Inter-Strand Locks for Genetic and Epigenetic Detection THE CURATORS OF THE UNIVERSITY OF MISSOURI 2016-06-23 US disclosed
WO-2015021055-A1 BASE-PAIR SPECIFIC INTER-STRAND LOCKS FOR GENETIC AND EPIGENETIC DETECTION THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) 2015-02-12 WO disclosed