Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | ARG1 | P05089 | 1/20 | 0.51 |
| ▸ | ARG2 | P78540 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PTPRA | P18433 | 1/20 | 0.38 |
| ▸ | PTPRB | P23467 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1695173 | 0.88 | SMN1; SMN2 (0.49) | SMN1; SMN2HIF1AARG1ARG2SLC6A2 | |
| SCHEMBL8351006 | 0.83 | SMN1; SMN2 (0.69) | SMN1; SMN2HIF1AARG1ARG2SLC6A2 | |
| SCHEMBL2172319 | 0.80 | SMN1; SMN2 (0.60) | SMN1; SMN2HIF1AARG1ARG2SLC6A2 | |
| SCHEMBL9457635 | 0.80 | SMN1; SMN2 (0.60) | SMN1; SMN2HIF1AARG1ARG2SLC6A2 | |
| SCHEMBL14743437 | 0.80 | SMN1; SMN2 (0.60) | SMN1; SMN2HIF1AARG1ARG2SLC6A2 | |
| SCHEMBL7514054 | 0.79 | SMN1; SMN2 (0.53) | SMN1; SMN2HIF1AARG1ARG2SLC6A2 | |
| SCHEMBL366770 | 0.78 | SMN1; SMN2 (0.62) | SMN1; SMN2HIF1AARG1ARG2SLC6A2 | |
| SCHEMBL7924236 | 0.78 | SMN1; SMN2 (0.62) | SMN1; SMN2HIF1AARG1ARG2SLC6A2 | |
| SCHEMBL22190022 | 0.78 | SMN1; SMN2 (0.62) | SMN1; SMN2HIF1AARG1ARG2SLC6A2 | |
| SCHEMBL366771 | 0.78 | SMN1; SMN2 (0.62) | SMN1; SMN2HIF1AARG1ARG2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150045328-A1 | DISUBSTITUTED ARYL OXY DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | ALLERGAN, INC. | 2015-02-12 | — | — | US | disclosed |
| WO-2015021112-A1 | DISUBSTITUTED ARYL OXY DERIVATIVES AS SPHINGOSINE-1- PHOSPHATE RECEPTORS MODULATORS | ALLERGAN, INC. (US) | 2015-02-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150045328-A1 | DISUBSTITUTED ARYL OXY DERIVATIVES AS SPHINGOSINE-1 PHOSPHATE RECEPTORS MODULATORS | S1PR1, S1PR3, S1PR2 | SMN1; SMN2 3562/4885HIF1A 2285/4885ARG1 3016/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.