Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.35 |
| ▸ | LYN | P07948 | 1/20 | 0.31 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | DAO | P14920 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29414450 | 0.86 | — | — | |
| N4-Hydroxycytosine SCHEMBL31006505 | 0.71 | — | — | |
| SCHEMBL2463454 | 0.70 | POLB (0.47) | POLBNPC1RAB9AKMT2AKCNH2 | |
| SCHEMBL655272 | 0.69 | KCNH2 (0.51) | POLBNPC1RAB9AKMT2AKCNH2 | |
| SCHEMBL30437427 | 0.67 | — | — | |
| SCHEMBL29515884 | 0.66 | POLB (0.50) | POLBNPC1RAB9AKMT2AKCNH2 | |
| Nitric Acid SCHEMBL31529980 | 0.62 | ALDH1A1 (0.67) | KMT2AMAPTTP53ALDH1A1RECQL | |
| Uracil SCHEMBL29525634 | 0.60 | — | — | |
| SCHEMBL4724282 | 0.58 | — | — | |
| Nitric Acid SCHEMBL125759 | 0.57 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015021055-A1 | BASE-PAIR SPECIFIC INTER-STRAND LOCKS FOR GENETIC AND EPIGENETIC DETECTION | THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) | 2015-02-12 | — | — | WO | disclosed |