Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 4/20 | 0.43 |
| ▸ | B3GNT2 | Q9NY97 | 1/20 | 0.42 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.38 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 2/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1643125 | 0.91 | CYP17A1 (0.40) | PDE2AB3GNT2CYP17A1CYP3A4NR1I2 | |
| SCHEMBL1285295 | 0.86 | PDE2A (0.43) | PDE2AB3GNT2CYP17A1CYP3A4NPSR1 | |
| SCHEMBL14378143 | 0.84 | PDE2A (0.46) | PDE2AB3GNT2CYP17A1CYP3A4LCK | |
| SCHEMBL1645545 | 0.83 | PDE2A (0.42) | PDE2ACYP3A4NPSR1DDR2RORC | |
| SCHEMBL1645409 | 0.82 | PDE2A (0.44) | PDE2ANPSR1PIN1TAS1R3TAS1R1 | |
| SCHEMBL1643314 | 0.81 | CYP17A1 (0.39) | PDE2ACYP17A1CYP3A4TAS1R3TAS1R1 | |
| SCHEMBL1644914 | 0.81 | PDE2A (0.45) | PDE2ACYP3A4NPSR1PIN1TAS1R3 | |
| SCHEMBL14378392 | 0.80 | CYP17A1 (0.41) | PDE2AB3GNT2CYP17A1CYP3A4NR1I2 | |
| SCHEMBL1285428 | 0.77 | CYP17A1 (0.39) | PDE2AB3GNT2CYP17A1CYP3A4NR1I2 | |
| SCHEMBL1644385 | 0.77 | MAOB (0.43) | PDE2ADDR2MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120088746-A1 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | PFIZER INC. (US) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088746-A1 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | TRPV1, TRPA1, TRPV2 | PDE2A 1116/4885B3GNT2 621/4885CYP17A1 4396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.