Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 18/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15536853 | 0.83 | SCN9A (0.68) | SCN9ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17244937 | 0.79 | SCN9A (0.36) | SCN9A | |
| SCHEMBL16448571 | 0.78 | SCN9A (1.00) | SCN9A | |
| SCHEMBL17240727 | 0.78 | SCN9A (0.38) | SCN9A | |
| SCHEMBL15544550 | 0.78 | SCN9A (0.36) | SCN9A | |
| SCHEMBL15036521 | 0.76 | SCN9A (0.38) | SCN9ASMN1; SMN2MAPT | |
| SCHEMBL15535576 | 0.75 | SCN9A (0.64) | SCN9A | |
| SCHEMBL16448572 | 0.75 | SCN9A (1.00) | SCN9A | |
| SCHEMBL16759102 | 0.74 | MGLL (0.41) | SCN9A | |
| SCHEMBL15036608 | 0.74 | SCN9A (0.60) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8952169-B2 | N-substituted benzamides and methods of use thereof | XENON PHARMACEUTICALS INC. (CA) | 2015-02-10 | — | — | US | disclosed |
| US-8952169-B2 | N-substituted benzamides and methods of use thereof | XENON PHARMACEUTICALS INC. (CA) | 2015-02-10 | — | — | US | disclosed |