Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 15/20 | 0.68 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16448706 | 0.83 | SCN9A (0.64) | SCN9ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL16448571 | 0.81 | SCN9A (1.00) | SCN9A | |
| SCHEMBL16448572 | 0.81 | SCN9A (1.00) | SCN9A | |
| SCHEMBL15536949 | 0.78 | SCN9A (1.00) | SCN9A | |
| SCHEMBL15536664 | 0.78 | SCN9A (0.54) | SCN9ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL31207479 | 0.77 | SCN9A (0.45) | SCN9AMRGPRX4 | |
| SCHEMBL31207449 | 0.76 | SCN9A (0.43) | SCN9A | |
| SCHEMBL3981224 | 0.75 | TSHR (0.45) | SCN9ASMN1; SMN2MRGPRX4 | |
| SCHEMBL15543742 | 0.72 | KEAP1 (0.42) | SCN9ASMN1; SMN2MRGPRX4 | |
| SCHEMBL15555174 | 0.71 | SCN9A (0.40) | SCN9AEPHX2MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2855428-A1 | N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN | Genentech, Inc. (US) | 2015-04-08 | — | — | EP | disclosed |
| US-8952169-B2 | N-substituted benzamides and methods of use thereof | XENON PHARMACEUTICALS INC. (CA) | 2015-02-10 | — | — | US | disclosed |
| US-8952169-B2 | N-substituted benzamides and methods of use thereof | XENON PHARMACEUTICALS INC. (CA) | 2015-02-10 | — | — | US | disclosed |
| WO-2013177224-A1 | N-SUBSTITUTED BENZAMIDES AND THEIR USE IN THE TREATMENT OF PAIN | GENENTECH, INC. (US) | 2013-11-28 | — | — | WO | disclosed |