Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | NAMPT | P43490 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12893204 | 0.86 | PLK1 (0.59) | SMN1; SMN2NAMPTALDH1A1RAB9ANPC1 | |
| SCHEMBL16448997 | 0.84 | SMN1; SMN2 (0.49) | SMN1; SMN2NAMPTALDH1A1RAB9ANPC1 | |
| SCHEMBL16448994 | 0.84 | NPC1 (0.67) | SMN1; SMN2NAMPTALDH1A1RAB9ANPC1 | |
| SCHEMBL21555454 | 0.84 | SMN1; SMN2 (0.61) | SMN1; SMN2NAMPTALDH1A1RAB9ANPC1 | |
| SCHEMBL13051958 | 0.84 | SMN1; SMN2 (0.61) | SMN1; SMN2NAMPTALDH1A1RAB9ANPC1 | |
| SCHEMBL12445445 | 0.84 | SMN1; SMN2 (0.81) | SMN1; SMN2NAMPTALDH1A1RAB9ANPC1 | |
| SCHEMBL32679738 | 0.83 | HPGD (0.66) | SMN1; SMN2ALDH1A1RAB9ANPC1KMT2A | |
| SCHEMBL8349985 | 0.83 | ALDH1A1 (0.73) | NAMPTALDH1A1RAB9ANPC1HDAC3 | |
| SCHEMBL15581457 | 0.83 | SMN1; SMN2 (0.59) | SMN1; SMN2NAMPTALDH1A1RAB9ANPC1 | |
| SCHEMBL25921197 | 0.83 | SMN1; SMN2 (0.59) | SMN1; SMN2NAMPTALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8952150-B2 | Prostaglandin transporter inhibitors and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2015-02-10 | — | — | US | disclosed |