Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12584132 | 0.87 | SMN1; SMN2 (0.59) | SMN1; SMN2NAMPTMEN1KMT2AGAA | |
| SCHEMBL16448996 | 0.85 | SMN1; SMN2 (0.55) | SMN1; SMN2NAMPTLMNAGAAMAPT | |
| SCHEMBL16448995 | 0.84 | SMN1; SMN2 (0.57) | SMN1; SMN2NAMPTMEN1KMT2AGAA | |
| SCHEMBL13753139 | 0.83 | L3MBTL1 (0.53) | SMN1; SMN2NAMPTCHRM1MEN1KMT2A | |
| SCHEMBL17905724 | 0.79 | MLYCD (0.59) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL22221700 | 0.78 | MLYCD (0.61) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL12445445 | 0.78 | SMN1; SMN2 (0.81) | SMN1; SMN2NAMPTMEN1KMT2ALMNA | |
| SCHEMBL17449186 | 0.77 | L3MBTL1 (0.44) | SMN1; SMN2NAMPTMEN1KMT2ALMNA | |
| SCHEMBL12893204 | 0.76 | PLK1 (0.59) | SMN1; SMN2NAMPTKMT2AHTTMAPT | |
| SCHEMBL16361209 | 0.76 | SMN1; SMN2 (0.84) | SMN1; SMN2NAMPTMEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8952150-B2 | Prostaglandin transporter inhibitors and uses thereof | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2015-02-10 | — | — | US | disclosed |