Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 2/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.42 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1644375 | 0.95 | HDAC3 (0.43) | PTGER4HRH3HDAC3HDAC2TRPV3 | |
| SCHEMBL1645086 | 0.92 | HDAC3 (0.44) | HRH3HDAC3HDAC2ACACBMAPT | |
| SCHEMBL1643367 | 0.91 | MAPT (0.45) | HRH3HDAC3HDAC2MAPTTP53 | |
| SCHEMBL1285568 | 0.89 | PTGER4 (0.39) | PTGER4HRH3HDAC3HDAC2TRPV3 | |
| SCHEMBL1285566 | 0.89 | PTGER4 (0.39) | PTGER4HRH3HDAC3HDAC2TRPV3 | |
| SCHEMBL1645116 | 0.89 | MAP3K5 (0.44) | HRH3HDAC3HDAC2MAPTTP53 | |
| SCHEMBL1644203 | 0.86 | HRH3 (0.42) | HRH3HDAC3HDAC2TRPV3ACACB | |
| SCHEMBL1284636 | 0.83 | HDAC3 (0.42) | PTGER4HRH3HDAC3HDAC2MAPT | |
| SCHEMBL1645194 | 0.81 | HDAC3 (0.41) | HRH3HDAC3HDAC2MAPTTP53 | |
| SCHEMBL1285305 | 0.81 | HDAC3 (0.41) | HRH3HDAC3HDAC2MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120088746-A1 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | PFIZER INC. (US) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088746-A1 | AMIDE DERIVATIVES AS ION-CHANNEL LIGANDS AND PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME | TRPV1, TRPA1, TRPV2 | PTGER4 198/4885HRH3 556/4885HDAC3 239/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.