Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 4/20 | 0.37 |
| ▸ | TUBB | P07437 | 4/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 4/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 4/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 4/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 4/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 4/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 4/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 4/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 4/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 4/20 | 0.37 |
| ▸ | TUBA1C | Q9BQE3 | 4/20 | 0.37 |
| ▸ | TUBB6 | Q9BUF5 | 4/20 | 0.37 |
| ▸ | TUBB2B | Q9BVA1 | 4/20 | 0.37 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.37 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15297324 | 0.87 | TTR (0.42) | ALDH1A1KDM4ETSHRTUBB4ATUBB | |
| SCHEMBL16450058 | 0.82 | GSK3B (0.42) | ALDH1A1KDM4ETUBB4ATUBBTUBA3C | |
| SCHEMBL15297493 | 0.79 | KMT2A (0.38) | ALDH1A1KDM4ETUBB4ATUBBTUBA3C | |
| SCHEMBL15958962 | 0.75 | IDO1 (0.53) | ALDH1A1KDM4EGSK3BIDO1TDO2 | |
| SCHEMBL3924578 | 0.71 | ALDH1A1 (0.56) | ALDH1A1TSHRNFE2L2TUBB4ATUBB | |
| SCHEMBL2002821 | 0.68 | ERN1 (0.59) | ALDH1A1TSHRNFE2L2TUBB4ATUBB | |
| SCHEMBL31227831 | 0.68 | DRD1 (0.49) | ALDH1A1TSHRNFE2L2TUBB4ATUBB | |
| SCHEMBL16450063 | 0.68 | ALDH1A1 (0.49) | ALDH1A1KDM4ETSHRTUBB4ATUBB | |
| SCHEMBL19417507 | 0.68 | — | — | |
| SCHEMBL17535738 | 0.66 | ALDH1A1 (0.46) | ALDH1A1KDM4ETSHRNFE2L2TUBB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2831063-B1 | SCHWEINFURTHIN ANALOGUES | UNIV IOWA RES FOUND (US) | 2017-10-04 | — | — | EP | disclosed |
| US-9428493-B2 | Schweinfurthin analogues | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2016-08-30 | — | — | US | disclosed |
| US-20150045404-A1 | SCHWEINFURTHIN ANALOGUES | UNIVERSITY OF IOWA RESEARCH FOUNDATION | 2015-02-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150045404-A1 | SCHWEINFURTHIN ANALOGUES | HRH4, HRH1, SUCNR1 | ALDH1A1 496/4885KDM4E 2671/4885TSHR 57/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.