Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | TDO2 | P48775 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PARG | Q86W56 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 9/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | PRKCA | P17252 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22159339 | 0.85 | SCN9A (0.51) | IDO1TDO2KDM4EALDH1A1CYP2A6 | |
| SCHEMBL31632863 | 0.85 | IDO1 (0.44) | IDO1TDO2KDM4EALDH1A1CYP2A6 | |
| SCHEMBL31632773 | 0.79 | SCN9A (0.44) | IDO1TDO2KDM4EALDH1A1CYP2A6 | |
| SCHEMBL121650 | 0.76 | IDO1 (0.58) | IDO1TDO2SCN9ASCN5A | |
| SCHEMBL121418 | 0.76 | IDO1 (0.58) | IDO1TDO2KDM4EALDH1A1PTGS1 | |
| SCHEMBL16452865 | 0.75 | ALDH1A1 (0.38) | IDO1TDO2KDM4EALDH1A1MEN1 | |
| SCHEMBL19831270 | 0.73 | CYP2A6 (0.50) | KDM4EALDH1A1CYP2A6MEN1KMT2A | |
| SCHEMBL9300549 | 0.73 | IMPDH2 (0.57) | IDO1TDO2KDM4EALDH1A1MEN1 | |
| SCHEMBL16474119 | 0.73 | IDO1 (0.55) | IDO1TDO2SCN9ASCN5A | |
| SCHEMBL147558 | 0.73 | IDO1 (0.58) | IDO1TDO2PTGS1SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |