Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 16/20 | 0.73 |
| ▸ | APP | P05067 | 3/20 | 0.66 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1645458 | 1.00 | BACE1 (0.73) | BACE1APPPTGS2MAPTMMP9 | |
| SCHEMBL1650914 | 0.86 | PTGS2 (0.82) | BACE1PTGS2MAPT | |
| SCHEMBL1650911 | 0.86 | PTGS2 (0.82) | BACE1PTGS2MAPT | |
| SCHEMBL3211811 | 0.85 | BACE1 (1.00) | BACE1APPPTGS2MAPTMMP9 | |
| SCHEMBL3211232 | 0.85 | BACE1 (1.00) | BACE1APPPTGS2MAPTMMP9 | |
| SCHEMBL3211817 | 0.85 | BACE1 (1.00) | BACE1APPPTGS2MAPTMMP9 | |
| SCHEMBL3211218 | 0.85 | BACE1 (1.00) | BACE1APPPTGS2MAPTMMP9 | |
| SCHEMBL1648423 | 0.84 | BACE1 (1.00) | BACE1PTGS2 | |
| SCHEMBL1648421 | 0.84 | BACE1 (1.00) | BACE1PTGS2 | |
| SCHEMBL1646352 | 0.84 | BACE1 (0.76) | BACE1APPMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552220-B2 | Therapeutic agent for Alzheimer's disease | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2013-10-08 | — | — | US | disclosed |
| EP-2305629-A1 | THERAPEUTIC AGENT FOR ALZHEIMER'S DISEASE | Tokyo Institute of Technology (JP) | 2011-04-06 | — | — | EP | disclosed |