Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | UGCG | Q16739 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.45 |
| ▸ | PDE1A | P54750 | 1/20 | 0.45 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.45 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16454882 | 0.98 | SMN1; SMN2 (0.54) | MAPTGAAMAPK1RXFP1TSHR | |
| SCHEMBL16454891 | 0.89 | NPSR1 (0.53) | MAPTGAAMAPK1TSHRALDH1A1 | |
| SCHEMBL16454892 | 0.88 | NPSR1 (0.52) | MAPTGAAMAPK1RXFP1TSHR | |
| SCHEMBL16454893 | 0.87 | NPSR1 (0.55) | MAPTGAAMAPK1RXFP1TSHR | |
| SCHEMBL16454857 | 0.81 | ALDH1A1 (0.50) | MAPTGAAMAPK1TSHRSMN1; SMN2 | |
| SCHEMBL16454797 | 0.80 | HTR1A (0.50) | MAPTGAAMAPK1TSHRSMN1; SMN2 | |
| SCHEMBL16454794 | 0.80 | ALDH1A1 (0.61) | MAPTGAAMAPK1RXFP1TSHR | |
| SCHEMBL16454799 | 0.79 | NPSR1 (0.47) | MAPTGAAMAPK1RXFP1TSHR | |
| SCHEMBL16454852 | 0.74 | KDM4E (0.47) | MAPTMAPK1TSHRSMN1; SMN2ALDH1A1 | |
| SCHEMBL16454887 | 0.74 | GAA (0.53) | MAPTGAAMAPK1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015020565-A1 | SUBSTITUTED [1,2,4]TRIAZOLO[4,3-A]PYRIDINES EXHIBITING ANTAGONIST PROPERTIES TO ADENOSINE A2A RECEPTORS, AND USE THEREOF | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "НЬЮВАК" (ООО "НЬЮВАК") (RU) | 2015-02-12 | — | — | WO | disclosed |