Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 8/20 | 0.43 |
| ▸ | PPARA | Q07869 | 6/20 | 0.43 |
| ▸ | PPARD | Q03181 | 4/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 6/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2431196 | 0.79 | PPARG (0.48) | PPARGPPARAPPARDMTNR1BHTR6 | |
| SCHEMBL12293713 | 0.76 | PPARG (0.43) | PPARGPPARAPPARDMTNR1BHTR6 | |
| SCHEMBL2428124 | 0.76 | PPARG (0.43) | PPARGPPARAPPARDMTNR1BHTR6 | |
| SCHEMBL14232191 | 0.76 | HTR6 (0.43) | PPARGPPARAPPARDMTNR1BHTR6 | |
| SCHEMBL15579819 | 0.75 | PPARG (0.45) | PPARGPPARAPPARDMTNR1BHTR6 | |
| SCHEMBL2430495 | 0.74 | PPARG (0.42) | PPARGPPARAPPARDMTNR1BHTR6 | |
| SCHEMBL2435242 | 0.73 | PPARG (0.42) | PPARGPPARAPPARDMTNR1BHTR6 | |
| SCHEMBL2432180 | 0.72 | HTR6 (0.41) | PPARGPPARAPPARDMTNR1BHTR6 | |
| SCHEMBL15579818 | 0.70 | PPARG (0.72) | PPARGPPARAPPARDHTR6AGTR1 | |
| SCHEMBL2428297 | 0.70 | MTNR1B (0.42) | PPARGPPARAPPARDMTNR1BHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079466-B1 | SUBSTITUTED INDOLE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2014-01-15 | — | — | EP | disclosed |