Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | NSD2 | O96028 | 1/20 | 0.41 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.41 |
| ▸ | PRKCB | P05771 | 1/20 | 0.41 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16457514 | 0.90 | TP53 (0.44) | TP53LMNAKDM4EHPGDMEN1 | |
| SCHEMBL16457697 | 0.89 | KDM4E (0.44) | TP53LMNAKDM4EHPGDMEN1 | |
| SCHEMBL16457157 | 0.89 | TP53 (0.44) | TP53LMNAKDM4EHPGDMEN1 | |
| SCHEMBL9894068 | 0.88 | TP53 (0.44) | TP53LMNAKDM4EHPGDMEN1 | |
| SCHEMBL1662482 | 0.88 | PRKCB (0.53) | TP53LMNAKDM4EHPGDNSD2 | |
| SCHEMBL9894161 | 0.85 | TP53 (0.42) | TP53LMNAKDM4EHPGDALDH1A1 | |
| SCHEMBL16457344 | 0.85 | PRKCB (0.43) | TP53LMNAKDM4EHPGDPRKCB | |
| SCHEMBL16457484 | 0.85 | TP53 (0.45) | TP53LMNAKDM4EHPGDTHRB | |
| SCHEMBL1662370 | 0.85 | TP53 (0.43) | TP53LMNAKDM4EHPGDMEN1 | |
| SCHEMBL16457090 | 0.85 | SYK (0.43) | KDM4EHPGDMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491032-B1 | AKT INHIBITORS | LILLY CO ELI (US) | 2014-04-16 | — | — | EP | disclosed |