Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16456980 | 0.90 | THRB (0.42) | KDM4EALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL16457367 | 0.89 | TP53 (0.44) | KDM4EALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL16457090 | 0.88 | SYK (0.43) | KDM4EALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL9927822 | 0.87 | KDM4E (0.44) | KDM4EALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL16457441 | 0.85 | KDM4E (0.40) | KDM4EALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL16457372 | 0.84 | THRB (0.42) | KDM4ETHRBMAPTCNR1GPR119 | |
| SCHEMBL16457324 | 0.84 | GPR119 (0.45) | KDM4EALDH1A1MEN1KMT2ATHRB | |
| SCHEMBL16457034 | 0.83 | TRPV3 (0.45) | KDM4EALDH1A1MEN1HPGDKMT2A | |
| SCHEMBL2063726 | 0.83 | THRB (0.44) | KDM4ETHRBMAPTCNR1GPR119 | |
| SCHEMBL16457456 | 0.83 | KDM4E (0.40) | KDM4EALDH1A1MEN1HPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491032-B1 | AKT INHIBITORS | LILLY CO ELI (US) | 2014-04-16 | — | — | EP | disclosed |