Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | PDE5A | O76074 | 16/20 | 0.50 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.48 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16458187 | 0.91 | ADORA3 (0.55) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL16244602 | 0.85 | ADORA3 (0.55) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL327099 | 0.85 | PDE5A (0.55) | ADORA3KCNH2PDE5A | |
| SCHEMBL9913921 | 0.83 | ADORA3 (0.54) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL9913970 | 0.81 | PDE5A (0.53) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL16457797 | 0.79 | PDE5A (0.52) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL16244626 | 0.79 | ADORA3 (0.55) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL15519039 | 0.79 | PDE5A (0.56) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL16458548 | 0.79 | PDE5A (0.48) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 | |
| SCHEMBL16458337 | 0.78 | ADORA3 (0.61) | ADORA3KCNH2PDE5AGUCY1A1GUCY1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2682394-A1 | 1H-pyrazolo[3,4-b]pyridin-triazine derivatives and their use for the treatment or the prevention of cardiovascular diseases | Bayer Intellectual Property GmbH (DE) | 2014-01-08 | — | — | EP | disclosed |