Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16457270 | 0.95 | THRB (0.37) | MAPTTHRBKDM4ESMN1; SMN2GAA | |
| SCHEMBL9894518 | 0.91 | GPR119 (0.38) | MAPTTHRBKDM4ESMN1; SMN2GAA | |
| SCHEMBL16457441 | 0.90 | KDM4E (0.40) | MAPTTHRBKDM4ESMN1; SMN2GAA | |
| SCHEMBL1662349 | 0.87 | THRB (0.36) | MAPTTHRBKDM4ESMN1; SMN2GAA | |
| SCHEMBL16457583 | 0.86 | KDM4E (0.39) | MAPTTHRBKDM4ESMN1; SMN2GAA | |
| SCHEMBL9927820 | 0.86 | GPR119 (0.40) | MAPTTHRBKDM4ESMN1; SMN2GAA | |
| SCHEMBL2063669 | 0.86 | THRB (0.38) | MAPTTHRBKDM4ESMN1; SMN2GAA | |
| SCHEMBL16457523 | 0.85 | GPR119 (0.38) | MAPTTHRBKDM4ESMN1; SMN2GAA | |
| SCHEMBL16457318 | 0.84 | HDAC4 (0.38) | MAPTTHRBKDM4ESMN1; SMN2GAA | |
| SCHEMBL16457157 | 0.84 | TP53 (0.44) | MAPTTHRBKDM4ESMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2491032-B1 | AKT INHIBITORS | LILLY CO ELI (US) | 2014-04-16 | — | — | EP | disclosed |